It has been our privilege to edit this volume which is complementary to the first book on Carbohydrate Metabolism in Pregnancy and the Newborn and which is based on work presented at the 2nd Aberdeen Colloquium bearing the same title held in April, 1978. The growth of knowledge of this subject in the 5-year period since the 1st Aber deen Colloquium in 1973 is truly remarkable and fully justifies this second exposition of current ideas in this field at the present time. For example, the 1973 meeting failed to cover such recent to pics as H. L. A. typing, glycosylated haemoglobin, control of glycae mia in labour with the use of the artificial pancreas, fetal brea thing and pregnancy specific B-glycoprotein and this volume provi des such an opportunity. The scope of this book is broader and in cludes data on placenta and fetal congenital anomaly related to ma ternal diabetes and many aspects of birthweight while there is also a section on maternal weight and nutrition in pregnancy. In a wider prospective one of the stimuli for such work has been the impetus given by the regular meetings starting in 1969 of the Diabetic Preg nancy Study Group of the European Association for the Study of Dia betes. This has allowed much more effective integration of research on diabetic pregnancy. The work of the members of the Diabetic Preg nency Study Group is widely represented in this publication.

Speakers at the 2nd Aberdeen Colloquium IX

Foreword XI11
Preface XV
1 Realignments of Metabolism
1.1 Intermediary Metabolism During Normal Pregnancy
1.2 Metabolic Changes in Pregnancy Relevant to Diabetes
1.3 Insulin Response Studies in Normal Pregnancy and Chemical Gestational Diabetes
2 Placental Structure Function and Blood Flow
2.1 Utero-Placental Blood Supply in Maternal Diabetes.
2.2 Placental Handling of Glucose
2.3 Utero-Placental Blood Flow. Methods of Determination, Clinical Application and the effect of Beta-Mimetic Agonists
2.4 Placental Changes in Gestational Diabetes
3 Endocrine Pancreas
3.1 The Maternal Endocrine Pancreas
3.2 Amino Acids and Development of the Beta Cell
3.3 The Relationship Between Glucagon and Hypocalcaemia in Infants of Diabetic Mothers
3.4 Pregnancy Related Factors Affecting Insulin Secretion
4 Fetal Nutrition and Macrosomia
4.1 Experimental Contributions to the Physiology of Fetal Macrosomia
4.2 Heavy-for-Dates Babies
4.3 Controlling Factors of Fetal Nutrition
5 Fetal Anomalies Related to Metabolism
5.1 Fetal Anomalies Related to Carbohydrate Metabolism: The Epidemiological Approach
5.2 Experimental Evidence Relating Fetal Anomalies to Diabetes
5.3 Congenital Malformations in Newborns of Diabetic Mothers
6 Antenatal Fetal Monitoring
6.1 Evaluation of Placental Steroids in Diabetic Pregnancy
6.2 Fetal Assessment in Diabetic Pregnancy Using Non-steroid Assessments
6.3 Management of the Pregnant Diabetic - When and How to Deliver
6.4 The Role of Pregnancy-Specific B1-Glycoprotein in the Management of Pregnancies Complicated by Diabetes
7 Symptomatic Diabetes
7.1 Management of Maternal Diabetes in Pregnancy
7.2 Sulphonylureas for Chemical Diabetes in Pregnancy
7.3 Management of Diabetes During Delivery with an Artificial Pancreas
7.4 Neonatal Problems
7.5 Preterm Labour and Perinatal Mortality in Diabetic Pregnancy - Obstetric Considerations
8 Asymptomatic Diabetes
8.1 Asymptomatic Diabetes in Pregnancy
8.2 Gestational Diabetes: Factors Influencing the Rates of Subsequent Diabetes
8.3 Detection of Chemical Gestational Diabetes
8.4 Qualitative Assessment of Children of Known Gestational Diabetec Mothers
9 Maternal Weight
9.1 Reproduction in Obese Women
9.2 Weight and Weight Gain in Pregnant Women
9.3 Glucose Tolerance in Complicated Pregnancies
9.4 Dieting in Pregnancy. A Study of the Effect of a High Protein Low Carbohydrate Diet on Birthweight on an Obstetric Population.