The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives.

In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. 

The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering. 

Part I. History

Chapter 1. History of Cardiac Pacing
Chapter 2. History of Defibrillation
Chapter 3. History of Cardiac Mapping
Chapter 4. History of Optical Mapping
Part II. Theory of Electric Stimulation and Defibrillation
Chapter 5. The Bidomain Theory of Pacing
Chapter 6. Bidomain Theory of Defibrillation
Chapter 7. The Generalized Activating Function
Part III. Electrode Mapping and Defibrillation
Chapter 8. Extracellular Mapping of Arrhythmia
Chapter 9. Critical Points and the Upper Limit of Vulnerability for Defibrillation
Chapter 10. Inverse Potential Methods of Cardiac Mapping
Chapter 11. Monophasic Action Potential
Part IV. Optical Mapping of Stimulation and Defibrillation
Chapter 12. Mechanisms of Isolated Cell Stimulation
Chapter 13. The Role of Microscopic Tissue Structure in Defibrillation
Chapter 14. Virtual Electrode Theory of Pacing
Chapter 15. The Virtual Electrode Hypothesis of Defibrillation
Chapter 16. Simulataneous Optical andElectrical Recording
Chapter 17. Advanced 3D Optical Mapping
Chapter 18. Electromechanical Optical Mapping Methods
Part V. Methodology
Chapter 19. The Bidomain Model of Cardiac Tissue: From Microscale to Macroscale
Chapter 20. Newer Models of Cardiac Tissue
Chapter 21. The Role of Electroporation
Chapter 22. RF Versus Cryo Ablation
Chapter 23. Electroanatomical Mapping
Part VI. Implications for Implantable Devices
Chapter 24. Lessons for the Clinical Implant
Chapter 25. Resonance and Feedback Strategies for Low-Voltage Defibrillation
Chapter 26. Pacing Control of Local Cardiac Dynamics
Chapter 27. Advanced Methods for Assessing the Stability and Control of Alternans
Chapter 28. The Future of Implantable Defibrillator
Chapter 29. Lessons Learnt from Implantable Cardioverter -Defibrillators Recordings
Part VII. Novel Arrhythmia Therapies
Chapter 30. Optogenetic Control of Arrhythmias
Chapter 31. Subcutaneous Defibrillation
Chapter 32. Future High-Resolution Mapping
Chapter 33. Conformal Electronics Therapy for Defibrillation
Chapter 34. Multistage Defibrillation Therapy
Chapter 35. Implantable Cardioverter Defibrillator to Cardiac Implantable Electronic Device
Chapter 36. Leadless Pacing
Chapter 37. Direct His-bundle Pacing
Chapter 38. Artificial Intelligence/Machine Learning/Deep Learning
Chapter 39. Wearable Devices for Ambulatory Cardiac and Respiratory Monitoring.