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Calcium Antagonists and Calcium Agonists: Fundamental Criteria and Classification
With 18 Figures and 5 Tables
Session I: Ca-Channels
Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists
Ca Entry into Vascular Smooth Muscle
Calcium Currents in Mammalian Central Neurones
Session II: Molecular Interactions
Chemistry of Dihydropyridines
Structure-Function Relationships of 1,4-Dihydropyridines: Ligand and Receptor Perspectives
Calcium Channels: Introduction into Their Molecular Pharmacology
The Dihydropyridine Receptors
A Proposed Pharmacological Role for Dihydropyridine Binding Sites in Heart and Coronary Smooth Muscle
Session III: Myocardial Effects
The Effects of 1,4-Dihydropyridine Type Ca2+-Channel Antagonists and Agonists on Intracellular [Ca2+] Transients Accompanying Twitch Contraction of Heart Muscle
Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridines
Effects of the Calcium Agonistic Dihydropyridine Bay K 8644 on the Heart
Myocardial Effects of Dihydropyridines in Patients
Session IV: Effects on Smooth Muscle
Effect of Dihydropyridines on Visceral Smooth Muscle
Effects of Ca2+ Antagonists on Isolated Rabbit Mesenteric Resistance Vessels as Compared to Rabbit Aorta
Effect of Dihydropyridine Calcium Channel Modulators on Isolated Peripheral and Cerebral Vessels
Effects of Ca+ +-Agonistic and Ca+ +-Antagonistic 1,4-Dihydropyridine Compounds on Tonic and Phasic Activation of Extramural Coronary Vasculature
Effects of Dihydropyridines on Human and Animal Isolated Vessels
Endothelium-Dependent Vascular Relaxation
Session V: Circulation
Coronary and Systemic Hemodynamic Effects of Dihydropyridines
Effect of a Dihydropyridine-Type Calcium Antagonist on CerebralBlood Flow and Metabolism
Calcium, Dihydropyridines and Resistance Vessel Tone
Differences Between Dihydropyridine and Non-Dihydropyridine Calcium Antagonists in Inotropic, Chronotropic, Dromotropic and Vascular Effects: Differences in Underlying Mechanism
Effects of Calcium Antagonists on Fixed and Dynamic Obstructions in Patients with Severe Coronary Artery Disease
Session VI: Hypertension
Effects of Calcium Antagonistic and Agonistic Dihydropyridines on Experimental Hypertension and Vascular Damage
On the Antihypertensive Properties of Nitrendipine, with Observations of Its Effects on Electrolyte Excretion
The Use of Calcium Antagonists in the Treatment of Arterial Hypertension
Calcium Antagonists for Identification of Mechanisms and Treatment in Patients with Essential Hypertension
Session VII: Tissue Protection
Dihydropyridines and the Protection of the Ischaemic and Anoxic Myocardium
Protection Against Complete Cerebral Ischemia by Nimodipine
Interdependence of Antihypertensive, Anticalcinotic, and Antiarteriosclerotic Effects of Calcium Antagonists - Model Experiments on Spontaneously Hypertensive Rats (SHR).