This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences.

 

This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Biopharmaceuticals Produced from Cultivated Mammalian Cells

Remote Control of Mammalian Therapeutic Designer Cells
Next generation cell engineering using microRNAs
An Omic's data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production
Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations
Monoclonal antibody glycoengineering for biopharmaceutical quality assurance
Next-generation cell engineering platform for improving recombinant protein production in mammalian cells
Manufacturing human pluripotent stem cells and differentiated progenitors
Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications
Process Design for hMSC Products in Stirred Tank Bioreactors
Bio-production of Adeno-associated virus for gene therapy
Scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale
Intensified and Continuous mAb Production with Single-Use Systems
Mathematical modelling of cell culture processes
Model-assisted design concepts for mammalian cell culture processes
Bioprocess monitoring and control
Industrial Monitoring of Cell Culture.