This book provides a comprehensive overview of the biology of the endoplasmic reticulum (ER) and the associated ER proteins, it discusses their structure, function and signaling mechanisms in the cell and their role in disease. This book also offers insights into the practical aspects of research and demonstrates the use of non-mammalian models to study the structure and function of the ER. Written by leading experts in the field, the book enables readers to gain a thorough understanding of current ER biology. It is intended for scientists and clinical researchers working on the endoplasmic reticulum in all its various roles and facets in health and disease. 

<p>A View of the Endoplasmic Reticulum Through the Calreticulin Lens

Structural Analysis of Calreticulin, an Endoplasmic Reticulum-Resident Molecular Chaperone
The Role of Endoplasmic Reticulum Chaperones in Protein Folding and Quality Control
Proteins Interacting with STIM1 and Store-Operated Ca²⁺ Entry
Endoplasmic Reticulum (ER) and ER-Phagy
Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum
Roles of Calreticulin in Protein Folding, Immunity, Calcium Signaling and Cell Transformation
Impact of Calreticulin and Its Mutants on Endoplasmic Reticulum Function in Health and Disease
Cancer Biology of the Endoplasmic Reticulum Lectin Chaperones Calreticulin, Calnexin and PDIA3/ERp57
Maintenance of Endoplasmic Reticulum Protein Homeostasis in Cancer: Friend or Foe
IP3 Receptor Biology and Endoplasmic Reticulum Calcium Dynamics in Cancer
Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders
Endoplasmic Reticulum Homeostasis and Stress Responses in <i>Caenorhabditis elegans</i>.- Tardigrada: An Emerging Animal Model to Study the Endoplasmic Reticulum Stress Response to Environmental Extremes.</p><p> </p><p><br></p><p> </p><p> </p>