Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood.
Two earlier volumes dedicated to the subject of obesity, published in the series "Advances in Biochemistry in Health and Disease" focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). 
This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.   

Cellular and biochemical mechanisms of obesity

The role of inflammation in obesity
Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity
The role of the inflammasome in obesity
Adipose tissue macrophages and their polarization in health and obesity
Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation
The interplay between adipocytes and immune system cells in the pathophysiology of obesity
Neuropeptides in Obesity and Metabolic Disease
Adiposity and the Role of Neuroendocrine Hormones in Energy Balance
Obesity in menopause
Ovarian hormones and obesity
The role of tissue-specific glucocorticoids in central obesity
Thyroid function in obesity
Glucocorticoid hormones: cause or cure for obesity
Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota
Recent advances in leptin and obesity
Pathophysiology of obesity due to neurohormonal dysregulation and autophagy
The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
Disturbance of neuronal signals in the pathophysiology of obesity
The sympathetic neuro-adipose connection and the control of body weight
Sympathetic activation in obesity
Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism
Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome
Should the sympathetic nervous system be a target to improve obesity?
Metabolic Syndrome and Oxidative Stress: A Complex Relationship
The role of oxidative stress in the pathogenesis of obesity
How effective are antioxidant supplements in obesity
Oxidative stress in obesity: a critical component in human diseases
Cellular mechanisms involved in the pathophysiology of obesity during oxidative stress
Oxidative stress and metabolic pathologies: from an adipocentric point of view
Oxidative stress contributes to the pathogenesis of obesity
The genetics of oxidative stress in obesity
Increased oxidative stress is associated with adipocyte fat accumulation
The vicious cycle of oxidative stress and obesity
GPCR-Mediated Signaling of Metabolites in the pathophysiology of obesity
Ceramide signaling in obesity
The role of the triggering receptor in the pathophysiology of obesity
The AMPK pathway in the development of obesity
Interleukin-1 superfamily: Divergent roles in obesity
Ghrelin Receptor Mutations and Human Obesity
Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism
JAK/STAT signaling pathway in the development of obesity
SIRT1 and SIRT3 as mediators for the development of obesity
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity
Interplay between Obesity and cGMP Signaling in adipose tissue.