This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives.

Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach.

Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

 

PREFACE

I Epidemiology
II Pathology and Biology
1 Pathology of brain metastases
2 Translationnal approaches
3 Molecular mechanisms driving brain metastases development
4 Genomics characterization of BM
5 BM cell partners and tumor microenvironment
6 Experimental models of Brain Metastases
III Clinical presentation and symptom management
7 Clinical presentation
8 Epilepsy in CNS metastases
9 Safety, tolerability and use of steroids in CNS metastasis patients
10 Thrombo-embolic complications in BM patients
IV Imaging
11 BM diagnosis and monitoring
12 Metabolic imaging of BM
13 Radiation necrosis and progression assessment and definition
V Surgery
14 Modern surgical techniques
15 Quality of surgical resection assessment
16 Indications and emerging concepts in the era molecular biology
VI Radiation Therapy
17 Stereotatic radiosurgery
18 WBRT
19 Combined radiation therapy and systemic treatment
VII Systemic treatment
20 Lung
21 Breast.-. 22 Melanoma
23 Miscellaneous
VIII Neurocognition and QoL
IV Leptomeningeal disease
X Prevention/Prohylaxis strategies
XI Prognosis and prognostic models
XII Clinical trials / Endpoints and outcome assessment.