This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy.

Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine. 

Epidemiology and Socioeconomic Impact of CNS Metastases

Basic Biology of Brain Metastasis
Preclinical Models of Brain Metastasis
Pathology of Brain Metastases
Role of Precision Medicine in Patients With CNS Metastasis
Classification of Brain Metastases
The Role of Advanced Imaging in the Management of Brain Metastases
Clinical Presentation of Central Nervous System Metastases
Management of Seizures in Brain Metastases
Cerebrovascular Complications in Patients With Cancer
Mood Disorders in Patients With CNS Metastases
Leptomeningeal Disease and the Role of Intrathecal Therapy
Paraneoplastic Neurological Disorders
Systemic Therapy of Brain Metastases: Lung Cancer
Systemic Therapy of Brain Metastases: Breast Cancer
Systemic Therapy for Brain Metastases: Melanoma
Systemic Therapy for Brain Metastases in Other Primary Cancers (Genitourinary, Gastrointestinal, Gynecology, Head/Neck)
Management of Solid Tumor CNS Metastases in Children
Basic Radiobiology and Radiation Physics Primer
Role of Whole Brain Radiotherapy
Stereotactic Radiosurgery Technology
Stereotactic Radiosurgery - Indications and Outcomes in Central Nervous System and Skull Base Metastases
Hypofractionated Stereotactic Radiosurgery (HF-SRS) in the Treatment of Brain Metastases
Challenges and Controversies in Stereotactic Radiosurgery
Synergy of Immunotherapy and Radiosurgery
Salvage Irradiation for Patients With Recurrent Brain Metastases
Applications of Stereotactic Radiosurgery for Brain Metastases
Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases
Neurocognitive Effects of Brain Metastases and Their Treatment
The Role of Surgery in the Management of Brain Metastases
Intraoperative Brachytherapy for Resected Brain Metastases
Laser Interstitial Thermal Therapy for Brain Metastases and Radiation Necrosis
Preventing Cranial Wound Complications in Cancer Patients
Introduction to Spinal Metastases
Epidemiology of Spinal Metastatic Disease
Bone Metabolism in Cancer
Systemic Therapies for Patients With Metastatic Spinal Disease
The Role of Advanced Imaging in Spinal Metastases
Decision Making Algorithms for Surgical Treatment of Spine Metastatic Disease
Biomechanics of Spinal Fixation in Metastatic Disease
Separation Surgery for Spinal Metastases
Vertebrectomy for Spinal Metastases
Minimally Invasive Surgery for Spinal Metastases
Deformity Secondary to Vertebral Body Metastases
Postoperative Complications and Spinal Metastases
Vertebral Augmentation Procedures for Treatment of Pathologic Vertebral Body Fractures
Spinal Laser Interstitial Thermal Therapy for Metastatic Tumors
Optimizing Wound Healing in Metastatic Spine Surgery
Contemporary Radiation for Spinal Metastasis and Spinal Cord Compression
Intraoperative Radiation for Spinal Metastatic Disease
Approach to Pain in Patients with Central Nervous System Metastases
Interventions for Refractory Pain in Cancer Patients
Complementary and Integrative Therapies (CIM) in Patients With CNS Metastasis
The Palliative Care of Patients With Brain Metastases.