In this volume, one of a series of monographs devoted to the problems of cerebral ischemia and related topics, we present the proceedings of an international conference on Cerebral Ischemia and Basic Mechanisms held in Bad Schachen/Lake Constance, Germany in June 1992. The enormous progress in research recently on the basic mechanisms associated with cerebral ischemia has provided greater insight into the pathophysiological mechanisms of reduced brain perfusion and decreased cerebral metabolism. The high technology instrumentation used to unravel the intricacies of cerebral blood flow and metabolism includes positron emission tomography and magnetic resonance imaging. A description of sophisticated neurophysiological techniques will give the reader insight into new models of reversible and irreversible tissue damage and changes at the molecular level have been described. The therapeutic approaches which have developed from this re search have been or will be used in clinical trials and will open new avenues in the treatment of stroke. The organizers of the meeting would like to thank the advisory board for its helpful suggestions and the Deutsche Forschungsgemeinschaft and other sponsors for their important support.

The Window of Opportunity for the Treatment of Cerebral Ischemia

The Window of Opportunity for the Treatment of Cerebral Ischemia
Energy Metabolism
Uncoupling of Flow and Metabolism in Early Ischemic Stroke
Recovery from Motor Stroke: Different Patterns of Functional Reorganisation in Individual Patients
Head Injuries: A Target for Neuroprotection
Changes in the Biophysical Environment of Water Following Focal Brain Ischemia in the Rat
Acidosis
Aspects of Acid-Base Homeostasis in Ischemia
Acidosis: A Marker for Penumbra or a Target for Treatment?
Astrocytic H+ and Ca2+ Changes: Implications for Ischemic Brain Injury
Anoxic Injury of Central Myelinated Axons: Nonsynaptic Ionic Mechanisms
In Vivo Nuclear Magnetic Resonance Observation of Cerebral Metabolism
Effects of Extracellular Acidosis on Glial Cell Intracellular pH: Evidence for a Glial Spatial H+ - Buffering Mechanism?
Intracellular Messengers
Calcium Channel Blockers Prevent Delayed Cerebral Ischemia After Intracranial Aneurysmal Subarachnoid Hemorrhage
Monosialoganglioside GM1 in Experimental Models of Stroke
What Are We Learning from Clinical Trials in Acute Cerebral Ischemia?
Threshold of Calcium Influx After Global and Focal Ischemia: Implications for the Window of Therapeutic Opportunity
Non-NMDA Glutamate Receptors in the Regulation of Neuronal Ca2+ and Excitotoxicity
Phenylalkylamine Calcium Antagonists as Cerebroprotective Agents
Intracellular Messengers After Ischemia
Influence of NMD A Receptor Antagonists on Glycine Receptor Isoform Expression in Spinal Cord Cultures
Effects of Calcium Antagonists on Experimentally Induced Carotid Intimal Proliferations
Excitatory Amino Aids and Excitotoxicity
Unsettled Role of Glutamate/Glutamate Receptors in Ischemic Excitotoxic Neuronal Damage
Neuroprotective Effects of 5-HT1A Receptor Agonists
In Vitro Ischemia in the Hippocampal Slice
Glial Swelling and Damage by Arachidonic Acid
Free Radicals, Protein Synthesis
Disturbances of Cerebral Protein Synthesis in Global and Focal Ischemia
Neurotrophin Expression and Gene Regulation in a Focal Cerebral Ischemia Model in the Rat
Nitroarginine Reduces Infarction After Middle Cerebral Artery Occlusion in Rats
No Appreciable Swelling of Cultured Neurons After Oxygen Deprivation, and Cell Damage Occasionally Aggravated by Oxygen Resupply
Gene Expression
Changes in Gene Expression After Brief Ischemic Insults as Potential Mediators of Induced Tolerance: Postischemic Temperature as a Variable Affecting the Stress Response
Heat Shock Gene Expression as a Marker of Ischemic and Other Types of Injury
Gene Expression and Functional Changes After Acute Ischemia: Age-Related Differences in Outcome and Mechanisms
Models of Neural Circuit Reorganization After Injury
Clinical Relevance of Gene Expression in Cerebral Ischemia
Leukocytes, Microcirculation, and the Coagulation System
Mechanisms of Leukocyte-Mediated No-Reflow and Tissue Injury in the Microcirculation
Microcirculatory Changes in Cerebral Ischemia
Current Evidence on a Pathophysiological Function of Leukocyte /Endothelial Interactions in Cerebral Ischemia
Do Leukocytes Contribute to the Brain Lesion That Begins When an Intracranial Artery Is Occluded?
Contribution of Neutrophils to Ischemic Brain Damage
Polymorphonuclear Leukocyte Adherence and Microvascular Reflow After Focal Cerebral Ischemia/Reperfusion
Activation of the Coagulation System and Concomitant Impairment of White Cell Rheology in Patients with Acute Cerebral Infarction
Microcirculatory Disturbance and Leukocytes: Influence of Leukocyte-Produced Superoxide on Red Blood Cell Aggregation
Small Volume Resuscitation in Hemorrhagic Shock by Hycellupertonic/Hyperoncontic Saline-Dextran: Effects on the Central Nervous System
Effects of Pentoxifylline on Recovery from Cerebral Ischemia and Reperfusion Injury
Regional Cerebral Blood Flow in Acute Stroke: Comparison of Two Calcium Antagonists.