YEAST-BASED CHEMICAL GENOMIC APPROACHES<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation - Chemogenomic Profiling: Elucidating the Mode of Action of Small Molecules<br>MIRCOARRAY-BASED STRATEGIES TO IDENTIFY UNKNOWN PROTEIN INTERACTIONS<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>COMPOUND COLLECTION SYNTHESIS FOR CHEMICAL BIOLOGY<br>Introduction<br>Chemical Probes - A Chemical Question with Biological Consequences<br>Diversity Oriented Synthesis (DOS)<br>Biology Oriented Synthesis (BIOS)<br>TARGET IDENTIFICATION AND VALIDATION OF A WNT/BETA-CATENIN PATHWAY MODULATOR<br>Introduction<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>ACTIVITY-BASED PROTEIN PROFILING OF CYS PROTEASES<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>THE USE OF PHOTOAFFINITY LABELING FOR THE IDENTIFICATION OF THE BINDING SITE OF THE ANTIBIOTIC LINEZOLID<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>SURGICAL STRIKES: USES OF ANALOG SENSITIVE TECHNOLOGIES TO TARGET KINASES OF INTEREST<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation: ASKA Technology - Applications in Molecular Biology<br>MODULATION OF PROTEIN-PROTEIN INTERACTIONS BY SMALL MOLECULES<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>TARGETED PROTEIN DEGRADATION IN LIVE CELLS<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>TRAPOXIN B: FROM TOTAL SYNTHESIS TO EPIGENETICS<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>NATIVE CHEMIAL LIGATION - A TOOL FOR CHEMICAL PROTEIN SYNTHESIS<br>Introduction<br>The Synthetic Challenge<br>The Chemical Approach - Native Chemical Ligation<br>Chemical Biological Research/Evaluation - The Ras-RBD Systems<br>USING SPLIT INTEINS TO PREPARE SEMI-SYNTHETIC PROTEINS AND TO STUDY THE MECHANISMS OF PROTEIN TRANS-SPLICING<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>ELUCIDATION OF THE RAS CYCLE WITH SEMI-SYNTHETIC PROTEINS<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>THE STUDY OF RAB GTPASE RECYCLING USING SEMI-SYNTHETIC PRENYLATED PROTEINS<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>DEVELOPMENT OF A MODEL CANCER VACCINE CANDIDATE BASED ON THE MUCl CELLULAR SURFACE GLYCOPEPTIDE EPITOPE<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>THE INTRODUCTION OF CHEMICAL REPORTER GROUPS BY BIOORTHOGONAL LIGATION REACTIONS FOR THE IMAGING OF CELL-SURFACE GLYCANS<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation<br>SEQUENCE SPECIFIC DNA-BINDING SMALL MOLECULES FOR PROTEIN RECRUITMENT AND MODULATION OF TRANSCRIPTION<br>Introduction<br>The Biological Problem - Targeting DNA with Small Molecules<br>The Chemical Approach: The Polyamide Rationale<br>Chemical Biological Research/Evaluation - Polyamides in Biological Applications<br>G-QUADRUPLEX LIGANDS AS TOOLS FOR ELUCIDATING C-MYC TRANSCRIPTIONAL REGULATION<br>Introduction<br>The Biological Problem<br>The Chemical Approach<br>Chemical Biological Research/Evaluation