This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification.

This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics. 

Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery

Hydroxamic Acid-Containing Peptides in the Study of Histone Deacetylases
Sirtuin Inhibitors and Activators
Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors
Lysine Methyltransferases and Their Inhibitors
PRMT Inhibitors
Lysine-Specific Histone Demethylases 1/2  (LSD1/2) and Their Inhibitors
Inhibitors of JmjC-Containing Histone  Demethylases
Chemical Compounds Targeting DNA Methylation and Hydroxymethylation
Applied Biophysics for Bromodomain Drug Discovery
Methyl-Readers and Inhibitors
Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? - Acetylation and Methylation in Asthma, COPD, and Lung Cancer
Structure-Based Design ofEpigenetic Inhibitors
Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks
Advanced Assays in Epigenetics.<br>