Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Chemogenomics in Drug Discovery

Chemogenomics Strategies for GPCR Hit Finding
Chemogenomics Approaches to GPCR Lead Finding
Diversity-Oriented Synthesis: A Challenge for Synthetic Chemists
Probing Protein Function with Small Molecules
Tamoxifen-Based Probes for the Study of Estrogen Receptor-Mediated Transcription
Protein Structure Similarity Clustering (PSSC) and Natural Product Structure as Guiding Principles for Chemical Genomics
Novel Strategies in Drug Discovery: Current Challenges in Biomolecular Screening.