The book helps the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and thus is of intense interest to all those interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

1 Human Chromosomes: Structural and Functional Aspects

2 DNA Lesions Induced by Ionizing Radiation
3 Effects of Ultraviolet Radiation on DNA
4 Double Strand Break Repair Mechanisms in Mammalian Cells
5 Backup Pathways of Nonhomologous End Joining May Have a Dominant Role in the Formation of Chromosome Aberrations
6 Targeted and Non-Targeted Induction of Chromosomal Rearrangements After Exposure to Ionizing Radiation
7 DNA Methylation Damage: Formation, Repair and Biological Consequences
8 Adducts, Sister-Chromatid Exchanges and Mutations Following Benzo[a]pyrene Exposure: a Review of Quantitative Data Followed by Some Considerations Regarding Risk
9 Analysis of DNA Double-Strand Breaks by Means of g-H2AX Foci
10 Comet Assay
11 Origin of Chromosome Aberrations: Mechanisms
12 Chromatin Structure and the Formation of Chromosomal Alterations
13 Role of Chromatin Structure and Activity in the Induction of Chromosomal Aberrations
14 A Biomedical Perspective of Telomere Structure and Function
15 Cytokinesis-Block Micronucleus Assay: a Comprehensive 'Cytome' Approach for Measuring Chromosomal Instability, Mitotic Dysfunction and Cell Death Simultaneously in One Assay
16 In Vivo Rodent Micronucleus Assay
17 Sister-Chromatid Exchanges
18 Fluorescence in Situ Hybridisation
19 The CAB and S&S Systems, and an Approach Towards the Classification of Complex Chromosome Exchanges
20 Aberration Patterns and Cell Cycle Progression Following Exposure of Lymphocytes to the Alkylating Agent Trenimon
21 Cytogenetic Analysis and Occupational Health
22 Biological Dosimetry
23 Statistical Methods for Biological Dosimetry
24 Retrospective Biological Dosimetry by FISH
25 Chromosomal Aberrations in Astronauts
26 Internet Information System and Literature Database on Biomedical Activities of Electromagnetic Fields: Cancer and Cytogenetic Effects
27 Interpreting Studies on Magnetic Fields and the Risk of Childhood Leukaemia: an Ongoing Challenge
28 Cytogenetic and Carcinogenic Effects of Exposure to Radiofrequency Radiation
29 Radiofrequency Radiation and Replication Studies
30 Chromosome Analysis in Cancer Patients: Applications and Limitations
31 Chromosomal Aberration in Peripheral Blood Lymphocytes of Healthy Subjects and Risk of Cancer.