Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

Human Chromosomes: Structural and Functional Aspects

DNA Lesions Induced by Ionizing Radiation
Effects of Ultraviolet Radiation on DNA
Double Strand Break Repair Mechanisms in Mammalian Cells
Backup Pathways of Nonhomologous End Joining May Have a Dominant Role in the Formation of Chromosome Aberrations
Targeted and Non-Targeted Induction of Chromosomal Rearrangements After Exposure to Ionizing Radiation
DNA Methylation Damage: Formation, Repair and Biological Consequences
Adducts, Sister-Chromatid Exchanges and Mutations Following Benzo[a]pyrene Exposure: a Review of Quantitative Data Followed by Some Considerations Regarding Risk
Analysis of DNA Double-Strand Breaks by Means of ?-H2AX Foci
Comet Assay
Origin of Chromosome Aberrations: Mechanisms
Chromatin Structure and the Formation of Chromosomal Alterations
Role of Chromatin Structure and Activity in the Induction of Chromosomal Aberrations
A Biomedical Perspective of Telomere Structure and Function
Cytokinesis-Block Micronucleus Assay: a Comprehensive "Cytome" Approach for Measuring Chromosomal Instability, Mitotic Dysfunction and Cell Death Simultaneously in One Assay
In Vivo Rodent Micronucleus Assay
Sister-Chromatid Exchanges
Fluorescence in Situ Hybridisation
The CAB and S&S Systems, and an Approach Towards the Classification of Complex Chromosome Exchanges
Aberration Patterns and Cell Cycle Progression Following Exposure of Lymphocytes to the Alkylating Agent Trenimon
Cytogenetic Analysis and Occupational Health
Biological Dosimetry
Statistical Methods for Biological Dosimetry
Retrospective Biological Dosimetry by FISH
Chromosomal Aberrations in Astronauts
Internet Information System and Literature Database on Biomedical Activities of ElectromagneticFields: Cancer and Cytogenetic Effects
Interpreting Studies on Magnetic Fields and the Risk of Childhood Leukaemia: an Ongoing Challenge
Cytogenetic and Carcinogenic Effects of Exposure to Radiofrequency Radiation
Radiofrequency Radiation and Replication Studies
Chromosome Analysis in Cancer Patients: Applications and Limitations
Chromosomal Aberration in Peripheral Blood Lymphocytes of Healthy Subjects and Risk of Cancer.