Due to sensitive molecular biological techniques, our understanding of chromosomal aberrations is steadily increasing. Provided here is a review of basic and applied aspects of the field. Chromosome structure, induction of DNA lesions by different clastogenic agents and their repair, induction of aberrations by agents which affect specific sequences in the DNA, and factors affecting induction and yield of chromosomal aberrations are covered.
Further, topics such as automation of aberration scoring, problems associated with using chromosomal aberrations and micronuclei in population monitoring and the importance of chromosomal aberration assays in mutagenicity testing of chemicals are included.

Radiation-Induced Formation of DNA Double-Strand Breaks in Plasmids and E.coli

UV-induced pyrimidine monoadducts and their in vivo photofootprints
Chromatin Structure, Hyperthermia and Repair of UV-Induced DNA Photolesions in Mammalian Cells
An Inherited Homogeneously Staining Region Derived from a Long-Range Repeat Family in the House Mouse
Detection of Genetic Imbalances in Tumor Genomes by Fluorescence in situ Hybridization with Tumor Genomic DNA and Subregional DNA Probes
Fluorescent in situ hybridization (FISH) in cytogenetical studies
The Use of Premature Chromosome Condensation and Chromosome Painting to Understand Chromosome Exchange Formation
The Role of DNA Double-Strand-Break Rejoining in Chromosome Damage and Repair
Investigations of Aberration Origins Using BrdUrd
Elucidation of Some Factors Involved in the Formation of Chromosomal Aberrations by Inhibiting the Repair Polymerase
Use of Antitopoisomerase Drugs to Study the Mechanisms of Induction of Chromosomal Damage
Search for Perturbations induced by X-irradiation in the G2 Phase of Human Lymphocytes
A Comparison of Radiation-Induced Aberrations in Human Cells Involving Early and Late Replicating X Chromosomes
Radioprotective Chemicals as Tools for Studying Mechanisms of Radiation-Induced Chromosome Damage in Human Lymphocytes
Factors Determining the Yields of Radiation-Induced Chromosomal Aberrations as Visualised by Means of Premature Chromosome Condensation in Interphase Cells
Synergism and adaptive response in the interaction of low dose irradiation with subsequent mutagenic treatment in G2 phase human lymphocytes
Responses of Radiosensitive Mutant Mammalian Cell Lines to Restriction Endonuclease induced DNA Double-Strand Breaks
Quantitative Localization of ChromatidBreaks Induced by Alu I in the Long Arms of Chromosomes Number 1 of Chinese Hamster Ovary (CHO) Cells by Microphotometric Scanning
"Life time" of AluI inside Glycerol-Induced Vesicles in CHO Cells
Progress in Automatic Dicentric Hunting
The Micronucleus Assay with Rodent Peripheral Blood and Acridine Orange Supravital Staining
The Formation of Micronuclei after Exposure to Ionizing Radiation
Excision Repaired Sites, Chromosome Breaks and Chromosome Loss Measured Simultaneously in Human Lymphocytes using the Cytokinesis Block Micronucleus Assay and Cytosine Arabinoside
The Potential of FISH for Meiotic Segregation Analysis
Reliable Chromosome Studies of Human Oocytes and Spermatozoa using the Gradual Fixation-Air Drying (GF-AD) Method
Nondisjunction by Failures in the Molecular Control of Oocyte Maturation
Cytogenetic and Molecular Investigations in Chromosomal Instability Syndromes
Distributions of Spontaneous Chromosomal Aberrations and of Spontaneous and Induced SCE and Micronuclei in Peripheral Lymphocytes from a Human Population
Does the Genetic Deficiency in ALDH2 Determine the Alcohol-Drinking Behavior and the Induction of Chromosome Alterations in Peripheral Lymphocytes by Alcohol?
Variability of chromosomal alterations in human peripheral lymphocytes of smokers and nonsmokers
Chromosome analysis in accidental, occupational and environmental radiation exposure
New Approaches to Design and Interpretation of in vitro Chromosomal Aberration Tests
Comments on Short-Term Cytogenetic Assays for Screening of Environmental Chemical Carcinogens
Localized Chromosomal Aberrations in the Heterochromatic q Arm of the X Chromosome in V79 Chinese hamster cells and the Implications for Industrial in vitro Cytogenetic Screening
CytogeneticStudies in Laboratory Animals Exposed by Inhalation to Mainstream Smoke or Environmental Tobacco Smoke
Evolutionary Aspects of Structural Chromosome Aberrations.