Researchers involved in the cytogenetics and molecular genetics of human tumors will welcome this comprehensive overview of the type of aberrations that chromosome 12 presents in human solid tumors. The authors study the implications for a cytogenetic subtyping of the tumors involved and strategies for identifying the molecular changes which underlie the karyotypic alterations.
The aberrations of chromosome 12 which the book deals with are very frequent chromosomal alterations in human tumors occuring in frequent benign mesenchymal tumors, such as uterine leiomyomas and lipomas, and in tumors of epithelial origin, such as pleomorphic adenomas of the salivary glands.

Cytogenetic Background

Specificity and Implications of Chromosome 12 Abnormalities in Pleomorphic Adenomas
Involvement of Chromosome 12 in Uterine Leiomyoma
Lipoma Cytogenetics
Involvement of Chromosome 12 in Well-Differentiated Liposarcoma
Breakpoints and Recipient Chromosomes in Pleomorphic Adenomas, Lipomas, and Uterine Leiomyomas - What Do They Tell Us?
Trisomy 12 Clusters to Tumors of the Female Genital Tract
Numerical Chromosome 12 Analysis of Carcinoma In Situ and Invasive Germ Cell Tumors of the Adult Testis: A Study Based on the Simultaneous Application of Interphase Cytogenetics and Immunohistochemistry on Tissue Sections
Cytogenetic and Molecular Studies of Clear-Cell Sarcoma of Tendons and Aponeuroses
The Molecular Genetics of Chromosome 12
Comparative Gene Mapping: Human Chromosome 12 and Mouse Chromosome 15
The Molecular Oncology of 12q13-15
Gene Analysis: Methods and Facts
Cell Lines from Tumors Showing 12q13-15 Aberrations
Analysis of DNA from a Specific Chromosome Region
Chromosome 12 Aberrations in Human Germ Cell Tumors: A Fluorescence In Situ Hybridization Inventory
Development and Characterization of Cell Lines from a Myxoid Liposarcoma with t(12;16)(q13;p11.2) and Trisomy 8
Amplification of the GLI and LRP/A2MR Loci in Tumor Cells: Is GLI only by Chance Coamplified Together with Another Gene Related to Tumor Progression?
Analysis of Solid Tumours with Recurrent Breakpoints in Chromosome Region 12q13-15 by Fluorescence In Situ Hybridization Using a Microclone Library
Isolation and Characterisation of NotI-end Cosmids Mapping to Human Chromosome 12p.