Coarse-Grained Modelling of DNA and DNA Self-Assembly
Coarse-Grained Modelling of DNA and DNA Self-Assembly
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
Finite Size Effects
Stuctural and Mechanical Properties of Model DNA
Thermodynamic Properties of Model DNA
Modelling DNA Tweezers
Modelling a DNA Walker.
A Novel DNA Model
MethodsFinite Size Effects
Stuctural and Mechanical Properties of Model DNA
Thermodynamic Properties of Model DNA
Modelling DNA Tweezers
Modelling a DNA Walker.
Ouldridge, Thomas E.
| ISBN | 978-3-642-30516-0 |
|---|---|
| Artikelnummer | 9783642305160 |
| Medientyp | Buch |
| Copyrightjahr | 2012 |
| Verlag | Springer, Berlin |
| Umfang | XII, 176 Seiten |
| Abbildungen | XII, 176 p. |
| Sprache | Englisch |
