Coarse-Grained Modelling of DNA and DNA Self-Assembly
E-Book
Coarse-Grained Modelling of DNA and DNA Self-Assembly
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
Ouldridge, Thomas E.
| ISBN | 9783642305177 |
|---|---|
| Artikelnummer | 9783642305177 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2012 |
| Verlag | Springer-Verlag |
| Umfang | 176 Seiten |
| Abbildungen | w. 44 ill., 25 col. ill. |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
