Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. 

 The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. 

This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). 

 Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. 

This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.

History of Colorectal Liver Metastases (CLM)

How and Why does CLM Occur
Biological Behaviour of CLM
Diagnostic Workup
Staging of CLM
Prognostic Factors
Clinical Scoring Systems-. Patient and Treatment Selection
The impact of Multimodal Team and Strategies
Evolution of Chemotherapy and Biologicals
Neoadjuvant
Conversion
Adjuvant treatment.- Palliative treatment
Intra-arterial chemotherapy
BEADS - chemoembolization
Immunotherapy and Vaccines
The role of surgery
Liver first
Combined resection
Staged resection
Resection + ablation
Special Techniques - PVE , ALLPS, Torsilli, Vascular Reconstruction
Parenchymal sparing surgery
Re-resection
Liver pedicle lymphadenectomy.-Anatomical, Physiological and Kinetic evaluation of the future liver remnant
Liver and EHD
The Issue of Surgical Margins.-Laparoscopic and Robotic Resection
Navigation and Enhanced reality
Liver transplantation for CLM
Ablative Techniques.-SIRT
External Radiation
Combined Treatment - MARCELO RIBEIRO.- Follow Up Strategy
Prognosis and Management of Recurrence
Experiences in different continents (LIVERMET SURVEY).