This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling.

This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained.

By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation:  A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.

Part I: OverviewChapter 1:  "An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine" Yoram Vodovotz and Gary An<br>Part II:  "Computational Modeling Methods and Biomedical Applications"Chapter 2: Translational Equation-based Modeling -Gilles ClermontChapter 3:  Agent-based Modeling in Translational Systems Biology -Gary An Chapter 4: Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -Yoram VodovotzChapter 5: Therapeutics as Control:Model-based approaches for control discovery -Chase Cockrell, Judy Day, Gary An<br>Part III: Translational Modeling of Sepsis and TraumaChapter 6: Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -Tim Billiar Chapter 7: Multiscale Equation-based Models: Insights for Inflammation and Physiological Variability -Ioannis AndroulakisChapter 8: In silicoTrials and Personalized Therapy for Sepsis and Trauma -Vodovotz, Bartels and AnChapter 9: Computational Modeling of the Coagulation Response -Scott Diamond<br>Part IV: Translational Modeling of Organ/Tissue Specific Inflammatory Disease Processes Chapter 10: Disorder of Localized Inflammation in Wound Healing -Stephen BadylakChapter11: Equation-based Models of Wound Healing and Collective Cell Migration -Julia Arciero and David SwigonChapter 12: Agent-based Models of Wound Healing -Yoram Vodovotz and Gary AnChapter 13: Tissue realistic translational modeling of gut inflammation -Chase Cockrell and Gary AnChapter 14: Data-DrivenModeling of Liver Injury, Inflammation, and Fibrosis -Ruben Zamora and Yoram VodovotzChapter 15: Computational Modeling of Tuberculosis -Denise Kirschner<br>Part V: Future Perspectives: Translation to ImplementationChapter 16:  "The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases"Gary An and Yoram Vodovotz