Recent developments in research on diabetes mellitus embrace basic disciplines such as physiology, biochemistry, morphology and evolving sub-specialities. Fundamental studies on the heterogeneous diabetic syndrome are oriented towards regulatory principles of cell metabolism, genetic control mechanisms of insulin biosynthesis and secretion, as well as autoimmune events implicated in selective destruction of pancreatic ß-cell. In parallel, efforts are made for a better understanding of normal versus impaired biological actions, both of insulin and insulin-like growth factor I, and the translocation process of glucose transporters in insulin-responsive target cells.

Thoughts on the Regulation of Adenylyl Cyclase Systems by Hormone-Sensitive G-Proteins: A Tribute to Albert E. Renold

Anabolic Response to Cell Swelling in the Liver
Intercellular Communication and Insulin Secretion
Expression of the Insulin Gene and Its Regulation
Implications of the Glucokinase Glucose Sensor Paradigm for Pancreatic ?-Cell Function
How Ca2+ and Other Signalling Pathways Control the Exocytosis of Insulin in the ?-Cell
The Mechanism of Insulin Receptor Binding, Activation and Signal Transduction
Cell Biology of Insulin Action on Glucose Transport: Looking Back
Insulin-like Growth Factor: Endocrine and Autocrine/Paracrine Implications and Relations to Diabetes Mellitus
On the Pathogenesis of Insulin-Dependent Diabetes Mellitus in Man: A Paradigm in Transition
Selected References from the Bibliography of Albert E. Renold, M.D.