Multimodal treatment lies at the heart of the improvement in cancer cure rates. However, the more aggressive the treatment, the more adverse effects in normal tissues can be anticipated. Against this background, a major paradigm shift has taken place in that there is a new focus on cancer survivorship and quality of life: the life worth saving must be worth living. This volume is based on the CURED II conference held in May 2007, which was attended by scientists from many leading institutions. The volume comprises 18 chapters by leading experts who address a variety of important topics relating to late treatment effects, such as mechanisms and evolution of injury, risk factors, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that it will assist the reader in understanding how to prevent and treat the long-term side-effects of irradiation, thus improving the quality of life of long-term survivors of cancer.

Concured: Defining the Leading Edge in Research of Adverse Effects of Treatment for Adult-Onset Cancers

Bioimaging In Vivo to Discern the Evolution of Late Effects Temporally and Spatially
Association Between Single Nucleotide Polymorphisms and Susceptibility for the Development of Adverse Effects Resulting from Radiation Therapy
Prospective Second-Cancer Risk Estimation for Contemporary Radiotherapeutic Protocols
Bioengineering in the Repair of Irradiated Normal Tissue by Bone Marrow Derived Stem Cell Populations
Development of a Queriable Database for Oncology Outcome Analysis
Post-Radiation Dysphagia
Lithium as a Differential Neuroprotector During Brain Irradiation
Risks and Surveillance of Second Malignant Tumors in Prostate and Bladder Cancer Survivors
Cardiotoxic Effects of Radiation Therapy in Hodgkin's Lymphoma and Breast Cancer Survivors and the Potential Mitigating Effects of Exercise
Biodetection and Biointervention: Cytokine Pathways as a Rationale for Anticytokine Interventions Post-Radiation
Late Toxicity from Hypofractionated Stereotactic Body Radiation
The Radiation Spectrum of Normal Tissue Toxicity and Tolerance - Multiorgan Domino Effect
Risk Factors for Second Malignancies Following Stem Cell Transplant.