This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists. The opening, general section discusses basics such as clinical manifestations, histopathology, mechanisms, risk factors, drug hypersensitivity in particular populations, and the full range of diagnostic methods. The second part of the book provides concise information on the most important drug classes and guides the reader on how to proceed when patients present with a suspected reaction. For each drug class, the current level of evidence for use of the different diagnostic tools, including skin tests, provocation tests, and in vitro tests, is clarified, and management options, outlined. The inclusion of helpful tables and algorithms is designed to aid in decision making. Drug hypersensitivityis among the more complex allergological issues, and this book will meet the needs of general practitioners, internists, and specialists.

Part I. General aspects of drug hypersensitivity

Chapter 1. Terminology, classifications, chronology
Chapter 2. Epidemiology
Chapter 3. Clinical manifestations: Cutaneous signs and syndromes
Chapter 4. Clinical manifestations: Other organs (kidney, gut, heart, brain etc.)
Chapter 5. Danger signs in drug hypersensitivity and severity SCORES
Chapter 6. Pathomechanisms in Drug Hypersensitivities
Part II. Diagnostic methods
Chapter 7. Skin tests
Chapter 8. Serological tests
Chapter 9. T cell tests
Chapter 10. Basophil activation tests
Chapter 11. Histopathology of drug induced exanthemas
Part III. Management
Chapter 12. Drug desensitization in immediate-type hypersensitivity
Chapter 13. Documentation allergy card/pass
Part IV. Drug hypersensitivity in specific populations
Chapter 14. Children and Adolescents
Chapter 15. HIV-Infection and AIDS
Chapter 16. Oncology. immune checkpoint Inhibitors
Chapter 17. MC releasing syndromes in drug hypersensitivity
Part V. Eliciting Drugs
Chapter 18. Penicillins
Chapter 19. Cephalosporin Allergy
Chapter 20. Other Antibiotics
Chapter 21. Other Antiinfectious drugs
Chapter 22. Analgesics and non-steroidal antiphlogistic drugs
Chapter 23. Periinterventional hypersensitivity: Anesthetic drugs and materials
Chapter 24. Muscle relaxants
Chapter 25. Anticoagulants
Chapter 26. Biological drugs
Chapter 27. Hormones (delayed)
Chapter 28. Vaccines
Chapter 29. Antiepileptic and psychotropic drugs
Chapter 30. PROTON PUMP INHIBITORS
Chapter 31. Diagnostic agents
Chapter 32. Hypersensitivity to blood pressure agents
Chapter 33. Iron preparations
Chapter 34. Vitamins and supplements
Chapter 35. Anti-tumor drugs / Cytostatics
Chapter 36. Photosensitizing drugs
Chapter 37. Topically applied drugs
Chapter 38. Additives: Preservatives, Antioxidants (sulfites), Colors, dyes and other.