This book is a practical guide on image-guided robotic (CyberKnife®) radiosurgery of the brain and the spine. The volume introduces the radiosurgical community to the potential of image-guidance in the treatment of neurosurgical diseases including neuro-oncological, vascular and functional disorders. Principles of image-guided radiosurgery, including physics and radiobiology are considered. Each chapter provides a critical review of the literature and analyses of several aspects to offer an assessment of single and hypofractionated treatments. Based on the authors' experience, tables or summaries presenting the treatment approaches and associated risks are included as well. Providing a practical guide to define the selection of dose, fractionation schemes, isodose line, margins, imaging, constraints to the structures at risk will support safe practice of neuroradiosurgery. This book aims to shed new light on the treatment of neoplastic and non-neoplastic diseases of the central nervous system using the CyberKnife® image-guided robotic radiosurgery system. It will be adopted by neurosurgery residents and neurosurgery consultants as well as residents in radiation oncology and radiation oncologists; medical physicists involved in radiosurgery procedures may also benefit from this book. 

Creating the Future.- CyberKnife Warfare in America: Battles at the Border Between Neurosurgery and Radiation Oncology.- The CyberKnife Robotic Radiosurgery System.- The Target Locating System for CyberKnife NeuroRadiosurgery.- Treatment Planning.- Small Field Dosimetry.- Quality Control.- Morphological Imaging.- Functional Imaging.- Diffusion Tensor Imaging (DTI) tractography.- Metabolic Imaging.- Radiobiology of Radiosurgery and Hypofractionated Treatments.- Organs at Risk (OAR) Tolerance in Hypofractionated Radiosurgery.- Brain Metastasis: Therapeutic, Diagnostic and Strategic Considerations.- Brain Metastasis: The Experience of the Burdenko Institute of Neurosurgery.- Multiple Brain Metastases.- Large Metastases and Tumor Bed.- Parasagittal and Convexity Meningiomas.- Skull Base Meningiomas.- High Grade Meningiomas and Hemagiopericytomas.- Perioptic Meningiomas.- Optic Nerve Sheath Meningiomas.- Vestibular Schwannomas.- Large Vestibular Schwannomas.- Pituitary Adenomas.- Craniopharyngiomas.- Malignant Gliomas.- Pilocytic Astrocytomas.- Pineal Tumors