Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56 th International Workshop of the Ernst Schering Research Foundation that focused on 'Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases'.
1;Preface;5 2;Contents;8 3;List of Editors and Contributors;10 4;1 Inhibition of IFN- . asaMethod of Treatment of Various Autoimmune Diseases, Including Skin Diseases;17 5;2 Cytokine Targeting in Psoriasis and Psoriatic Arthritis: Beyond TNFa;44 6;3 Inhibitors of Histone Deacetylases as Anti- inflammatory Drugs;60 7;4 Dendritic Cell Interactions and Cytokine Production;76 8;5 Lysosomal Cysteine Proteases and Antigen Presentation;96 9;6 DCs and Cytokines Cooperate for the Induction of Tregs;111 10;7 Induction of Immunity and Inflammation by Interleukin- 12 Family Members;121 11;8 The Role of TNFa and IL- 17 Signaling- Induced Inflammatory Diseases in IL- 1 Receptor Antagonist- Deficient Mice in the Development of Excess IL- 1;142 12;9 TGFß- Mediated Immunoregulation;167 13;10 TNF Blockade : An Inflammatory Issue;173 14;11 IL- 1 Family Members in Inflammatory Skin Disease;199 15;12 Regulatory T Cells in Psoriasis;204
Numerof, Robert
Dinarello, Charles A.
Asadullah, Khusru
| ISBN | 9783540376736 |
|---|---|
| Artikelnummer | 9783540376736 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2007 |
| Verlag | Springer-Verlag |
| Umfang | 209 Seiten |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
