Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56^th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".

Inhibition of IFN-? as a Method of Treatment of Various Autoimmune Diseases, Including Skin Diseases

Cytokine Targeting in Psoriasis and Psoriatic Arthritis: Beyond TNF?
Inhibitors of Histone Deacetylases as Anti-inflammatory Drugs
Dendritic Cell Interactions and Cytokine Production
Lysosomal Cysteine Proteases and Antigen Presentation
DCs and Cytokines Cooperate for the Induction of Tregs
Induction of Immunity and Inflammation by Interleukin-12 Family Members
The Role of TNF? and IL-17 in the Development of Excess IL-1 Signaling-Induced Inflammatory Diseases in IL-1 Receptor Antagonist-Deficient Mice
TGF?-Mediated Immunoregulation
TNF Blockade: An Inflammatory Issue
IL-1 Family Members in Inflammatory Skin Disease
Regulatory T Cells in Psoriasis.