DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells therefore put a great deal of resources into repairing any damage to this precious store. Mechanisms of DNA repair vary greatly in their level of complexity, from specific reversal mechanisms that involve a single protein, to sequential pathways that require many enzymes. But at the heart of all these mechanisms lie proteins that recognize damage to DNA, raising important questions about how damaged DNA may be distinguished. These recognition processes are now finally yielding their secrets to structural analysis. This volume focuses on DNA repair, with an emphasis on structural data where available.

Repair of Alkylated DNA by the E. coli Ada Protein

Structural Phylogenetics of DNA Base Excision Repair
Protein Interactions in Mammalian Pathways of DNA Base Excision Repair
Poly(ADP-Ribose) Polymerase Is Required for Maintenance of Genomic Integrity During Base Excision Repair
Functional Domains of the E. coli UvrABC Proteins in Nucleotide Excision Repair
Nucleotide Excision Repair in Yeast: Recent Progress and Implications
Nucleotide Excision Repair in Man
Transcription-Coupled and Global Genome Nucleotide Excision Repair
DNA Mismatch Repair
Eukaryotic Mismatch Repair
Conflicting Roles of Mismatch and Nucleotide Excision Repair in Cellular Susceptibility to Anticancer Drugs
Crystallographic Studies of Proteins Involved in Recombinational Repair and Excision Repair
Eukaryotic DNA Ligases and DNA Repair.