This book is a continuance of the topic: "DAMPs in Human Diseases", the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases.

Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs ("SAMPs") is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities.

Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work.

The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists.

 

Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses

Part I. Prologue

Perspectives of the Danger/Injury Model in Immunology
Part II. A Select, Clinically Oriented Update of Topics Presented in "Damage-Associated Molecular Patterns in Human Diseases"; Volume 1: Injury-Induced Innate Immune Responses
Pattern Recognition Molecules
The Growing World of DAMPs
The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death
DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation
DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis
Part III. DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases
DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics
DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma
Solid Organ Injury
Atherosclerosis
Cerebro - Cardiovascular Diseases
Part IV. Epilogue
The "DAMPome" as a Key Player in the Pathogenesis of Human Diseases