This book provides in the first part an overview of dendritic cell (DC) biology and the role of DCs in some human diseases. The second part of the book illustrates some of the way that DCs can be manipulated for immunotherapy to either induce tolerance in autoimmunity and transplantation or enhance the immune responses such as in infection or cancer.

Part I: Biology of Dendritic Cells

Activation of Dendritic Cells by Toll-Like Receptors and C-Type Lectins. Dendritic Cell Migration to Peripheral Lymph Nodes. Dendritic Cells in Viral Infections
Part II: Role of Dendritic Cells in Disease.-Dendritic cells and their potential implication in pathology and treatment of Rheumatoid Arthritis. Lung Dendritic Cells: Targets for Therapy in Allergic Disease. Dendritic Cells in Rhinitis. Role of Epidermal Dendritic Cells in Drug Induced Cutaneous Adverse Reactions
Part III: Manipulation of Dendritic Cells for Immunotherapy
T cell Regulatory Plasmacytoid Dendritic Cells. Use of Aspirin and The Induction of Tolerance by Dendritic Cells. Use of Rapamycin in the Induction of Tolerogenic Dendritic Cells. Use of dexamethasone in the induction of tolerogenic Dendritic Cells. Induction of Tolerogenic Dendritic Cells by Vitamin D Receptor Agonists. Use of Adenovirus in vaccines for HIV. IFN-alpha in The Generation of Dendritic Cells for Cancer Immunotherapy. Dendritic cell-based immunotherapy in myeloid leukaemia: Translating fundamental mechanisms into clinical applications.