In this book, tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.

The Hedgehog Signaling Pathway in Cancer

The Rac/Rho GTPase Signaling
Developmental Biology of Fibroblasts and Neoplastic Disease
The Extracellular Matrix during Development and Neoplastic Growth
Wilm s Tumour: Starting off the Kidney all Over Again?- Testicular Teratoma: back to Pluripotent Stem Cells
Tumor Suppressors APC and VHL: Gatekeepers of the Intestine and Kidney
Hormonal and Stromal Regulation of Normal and Neoplastic Prostatic Development
Neoplastic Growth Through the Developmental Stages of the Human Organism.