I was gratified by the most favorable reception and wide usage received by the first edition of this book. A decade seems to be a short period for a book on pathology, and yet it witnessed many important changes of concepts, along with a formidable growth of knowledge. The second edition required extensive reorganization. There are new chapters on mitochondriopathies, on peroxisomal diseases and on spongy myelino pathies. Major revisions and new additions were necessary in many chapters, for instance those on the dysplasias of the cerebral and of the cerebellar hemispheres, which were largely reorganized. The chapters on perinatal pathology were reordered and reorganized to give a more logical sequence of prenatal, perinatal and postnatal lesions. The entire text was worked over for brevity. A wealth of new references was added with the. aim of staying abreast with the literature up to summer 1988. All refer ences were double checked for errors. My gratitude goes to Mrs. Gisela Ropte and Mrs. Cynthia Bunker for their untiring, diligent help. As a result, this second edition is an essentially rewritten text. Advance in the prevention of human suffering is based on a thorough understand ing of the nature of disease. I hope that this text will continue to be of service in this behalf. Perhaps it may also reflect and foster the intellectual curiosity which makes the "reading of brains" so interesting an occupation. Gottingen, 1989 Reinhard L.

Introduction: Normal Development and Basic Reactions

1. Gross and Microscopic Development of the Central Nervous System
2. Some Features of Basic Reactions Characteristic for Immature Nervous Tissue
First Part: Acquired Lesions in Newborns and Infants
3. Porencephaly, Hydranencephaly, Multicystic Encephalopathy
4. Hemorrhages in Asphyxiated Premature Infants
5. Lesions of Traumatic Birth and Other Causes of Hemorrhage
6. Perinatal Lesions of White Matter
7. Perinatal Lesions of Gray Matter
8. Postnatal Lesions of Gray Matter
9. Kernicterus (Bilirubin Encephalopathy)
10. Arterial Diseases in Infancy
11. Thrombosis of Intracranial Sinus and Veins
12. Cerebral Lesions in Congenital Cardiac Disease
13. Craniocerebral Trauma in Infancy
14. Infections of the Fetus
15. Purulent Leptomeningitis in Newborns and Infants
16. Meningoencephalitic Processes in the Peri- and Postnatal Periods, Including CNS Involvement by some Hematologic Diseases
17. Subdural Hematomas, Hygromas and Effusions
18. Meningeal Cysts
19. Hydrocephalus - Basic Concepts and General Pathology
20. Hydrocephalus - Special Pathology
Second Part: Malformations
21. Spina Bifida and Related Spinal Lesions
22. Forms of Hindbrain Crowding, Including the Arnold-Chiari Malformation
23. Anencephaly, Rachischisis, Encephaloceles and Related Lesions, Syndromes with Encephaloceles
24. Ventral Dysraphic and Various Sacral Lesions
25. Disturbances in Bulk Growth: Megalencephaly, Micrencephaly, Atelencephaly and Others
26. Dysplasias of the Cerebral Hemispheres
27. Dysplasias of Cerebral Cortex
28. Dysplasias of Cerebellum
29. Dysplasias of Cerebellar Cortex
30. Dysplasias of Brain Stem and Spinal Cord
31. Dysplasias in Chromosome Anomalies
32.Dysplasias of Cerebral Vessels
Third Part: Metabolic Diseases
33. Diseases of Carbohydrate Metabolism
34. Sphingolipidoses
35. Ceroid-Lipofuscinosis and Miscellaneous Lipidoses
36. Metachromatic Leukodystrophy (Sulfatase A Deficiency) and Multiple Sulfatase Deficiency
37. Globoid Cell Leukodystrophy
38. Peroxisomal Diseases
39. Mitochondrial Diseases
40. Spongy Myelinopathies
41. Diseases of Amino Acid Metabolism
42. Patchy Myelinopathies: Pelizaeus-Merzbacher Disease, Cockayne Syndrome, and Others, also Including a Review of Primary Cerebral Mineralizations
43. Alexander Disease
44. Axon Dystrophies.