This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world's foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Mitochondrial Medicine: an Historical Point of View,- Mitochondrial Biology and Function

Mitochondrial Genetics
Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS Syndrome)
Myoclonic Epilepsy with Ragged Red Fibers (MERRF Syndrome)
Leber Hereditary Optic Neuropathy (LHON)
Progressive External Ophthalmoplegia (PEO)
Leigh Syndrome
Mitochondrial Depletion Syndromes
Mitochondrial Neurogastrointestinal Encephalopathy (MNGIE)
Mitochondrial Neurodegenerative Disorders I: Dementia and Parkinsonisms
Mitochondrial Neurodegenerative Disorders II: Ataxia & Dystonia, Leukidystrophies
Mitochondria & Heart
Mitochondria & Liver
Mitochondria & Respiratory Involvement
Mitochondrial Endocrinology
Diagnostic Approach to Mitochondrial Disease
Mitochondrial Replacement Approaches
Exercise/Training
Mitochondrial Symptomatic Treatments
Experimental Therapies.