This book, now in a second revised edition, casts light on the often complex diagnosis of musculoskeletal tumors and tumor-like conditions by drawing on the experience of the Rizzoli Orthopedic Institute during more than 100 years of treatment and research in the field. The different entities are described from a multidisciplinary perspective, highlighting clinical, radiological, and histological correlations. Particular emphasis is placed on differential diagnosis, which often needs to take into account nontumoral conditions. The recent identification of further significant biological and genetic features, and the impact of these discoveries on the classification of round cell tumors, vascular lesions, and spindle/pleomorphic entities in bone, is also extensively discussed. The Rizzoli case archive dates back to September 1900 and contains the original material relating to more than 29,000 bone lesions and 11,000 soft tissue lesions . It is a fabulously rich resource, and this book will be invaluable for pathologists, radiologists, and clinicians at all levels of experience.

PART I INTRODUCTION Chapter 1 Epidemiology of Bone Lesions

Chapter 2 Classification of Primary Bone Lesions
Chapter 3 General Principles of Bone Pathology
Chapter 4 Epidemiology of Soft Tissue Lesions
Chapter 5 Classification of Soft Tissue Lesions
Chapter 6 General Principle of Soft Tissue Pathology and Molecular Alterations in Musculoskeletal Lesions
Chapter 7 General Principles of Imaging
Chapter 8 Staging.- PART II PSEUDOTUMORAL AND BENIGN LESIONS OF BONE Chapter 9 Simple Bone Cyst (Unicameral Bone Cyst)
Chapter 10 Langerhans Cell Histiocytosis
Chapter 11 Histiocytic Fibroma
Chapter 12 Fibrous Dysplasia
Chapter 13 Osteofibrous Dysplasia of Long Bones
Chapter 14 Desmoid Fibroma (Desmoplastic Fibroma of Bone)
Chapter 15 Chondromas
Chapter 16 Osteochondromas
Chapter 17 Chondroblastoma
Chapter 18 Chondromyxoid Fibroma
Chapter 19 Osteoid Osteoma
Chapter20 Osteoblastoma
Chapter 21 Aneurysmal Bone Cyst (ABC)
Chapter 22 Giant Cell Tumor
Chapter 23 Biology of Giant Cell Tumor
Chapter 24 Other Rare Pseudotumoral Lesions:
Chapter 25 Other Rare Benign Lesions.- PART III BENIGN LESIONS OF SOFT TISSUES Chapter 26 Myositis Ossificans
Chapter 27 Pigmented Villonodular Synovitis and Giant Cell Tumor of the Tendon Sheaths (Tenosynovial Giant Cell Tumor)
Chapter 28 Synovial Chondromatosis
Chapter 29 Fibromatosis (All Types)
Chapter 30 Lipomas
Chapter 31 Neurofibroma
Chapter 32 Schwannoma
Chapter 33 Other Rare Conditions of Pseudotumoral and Benign Lesions of Soft Tissues.- PART IV PRIMARY MALIGNANT TUMORS Chapter 34 Chondrosarcomas (CHS)
Chapter 35 Biology of Conventional Chondrosarcoma
Chapter 36 Osteosarcomas (OS)
Chapter 37 Biology of Osteosarcomas
Chapter 38 Chemotherapy of Osteosarcoma
Chapter 39 Small Blue Round Cell Tumors
Chapter 40 Biology of Ewing Sarcoma
Chapter 41 Chemotherapy of Ewing Sarcoma
Chapter 42 Fibroblastic/Myofibroblastic Tumors
Chapter 43 Nerve Sheath Tumor
Chapter 44 Smooth and Striated Muscle
Chapter 45 Sarcomas with Uncertain Differentiation
Chapter 46 Vascular Tumors
Chapter 47 Liposarcomas
Chapter 48 Chemotherapy of Soft Tissue Sarcomas
Chapter 49 Adamantinoma
Chapter 50 Notochordol Differentiation
Chapter 51 Other Rare Malignant Lesions.- PART V SYSTEMIC LESIONS Chapter 52 Primary Lymphoma of Bone
Chapter 53 Multiple Myeloma
Chapter 54 Hodgkin's Disease in Bone
Chapter 55 Metastatic Lesions.