Few advances in MR imaging have had the impact degenerative neurologic disorders, white matter d- that dif usion-weighted (DW) imaging has had in the eases, toxic/metabolic disorders, and tumors. As one evaluation of brain. From the time of the early de- can easily see from the table of contents, the authors scriptions by LeBihan and colleagues of the ability have systematically covered all major areas of neu- to image and measure the micromovement of water radiology. T is will allow cross-referencing to pr- molecules in the brain to the present time, dif usion lematic cases which one may encounter. Additionally, imaging and its derivatives have made an impact in knowledge of what represents a normal adult brain the evaluation of multiple disease processes, primar- and a normal developing brain along with an exp- ily in ischemia, but also in other conditions of the nation of artifacts seen in DW imaging makes this a brain. In most medical centers dif usion imaging is valuable book. It is noteworthy that the authors have no longer considered a sequence to be used in spe- chosen to abundantly illustrate the clinical material, cial circumstances, but rather it is employed as part drawing on pathologic correlations in a number of of routine MR imaging of the brain. Because the in- areas.

Principles of diffusion-weighted imaging

Normal brain and artifacts
Brain edema: Classification. Cytotoxic edema. Edema of neuron and glial cell. Intramyelinic edema. Axonal edema. Vasogenic edema
Infarction: Arterial infarction. Venous infarction
Dementia: Alzheimer's. Multi-infarct dementia. Other dementias. HIV dementia
Hemorrhage
Vasculitis/Vasculopathy: Behcet. Systemic lupus erythematosus. Posterior reversal encephalopathy syndrome. Drug induced
Epilepsy: Postictal encephalopathy. Status epilepticus
Demyelinating and degenerative diseases: ADEM. Multiple sclerosis. Creutzfeldt-Jakob disease
Toxic and metabolic diseases: Drug-induced encephalopathy. Mitochondrial encephalopathy. Phenylketonuria. Osmotic myelinolysis. Marchiafava-Bignami disease
Infectious diseases: Brain abscess. Extra-axial abscess. Encephalitis. Septic emboli
Trauma: Diffuse axonal injury. Brain contusion
Brain neoplasm: Epidermoid. Meningioma. Lymphoma. GBM. Metastasis. PNET
Pediatrics.