The rapid advances in medicine over the last 50 years have totally changed the outlook for children with disorders of sex development (DSD), but there is still much to learn. This book crystallizes the combined experience of a leading dedicated unit over 25 years in delivering expert medical and surgical care to children with DSD in a holistic environment. It documents the most recent advances in the molecular biology and embryology of sex development, and describes each disorder in detail. The clinical presentation and approach to diagnosis are described both for babies and for children presenting later in childhood or at adolescence. The chapters on management highlight all the latest knowledge and include the shared wisdom of the authors on current controversies, such as the timing of surgical treatment. Finally, the authors describe their short-, medium-, and long-term outcomes, which demonstrate the strengths of holistic team management.

The molecular basis of gonadal development and disorders of sex development

Embryology of the human genital tract
The hormones regulating sex development
Questions about gender - children with atypical gender development
Abnormal embryology in DSD
46XX Disorders of Sex Development
46,XY DSD
Mixed Sex chromosome (aneuploidy) and ovo-testicular DSD
Non-hormone DSD
Multiple malformation syndromes in DSD
The neonatate with ambiguous genitalia
DSD later in childhood
The adolescent or young adult with DSD
Imaging in DSD
Ethical principles for the management of infants with DSD. The medical management of DSD
Surgical treatment in infancy
Laparoscopy for DSD
The family
Genetic Counselling
Cultural differences and controversies about timing of management
Medical management of adolescents and young adults
Gynaecological management
Psychological Management in Adolescence and Beyond
Short, medium and long-term outcomes following surgery for DSD at Royal Children's Hospital
Long-term outcome of DSD: a world view
Complete Androgen Insensitivity Syndrome (A guide for parents and patients).