Unique work on structure-based drug design, covering multiple aspects of drug discovery and development Fully colored, many images, computer animations of 3D structures (these only in electronic form) Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design Structures by mode of action, no therapeutic areas Of high relevance for academia and industrial research Focus on
- gene technology in drug design, omics-technologies
- computational methods
- experimental techniques of structure determination
- multiple examples on mode of action of current drugs
- ADME-tox properties in drug development
- QSAR methods
- combinatorial chemistry
- biologicals, ribosome, targeting protein-protein interfaces

Part I Fundamentalsin Drug Research

1. Drug Research Yesterday, Today and Tomorrow
2. The Role of Serendipityin Drug Research
3. Classical Drug Research
4. Protein-Ligand Interactionsas the Basis for Drug Action
5. Optical Activity and Biological Effects
Part II Discovery and Optimizationof Lead Compounds
6. Screeningfor Lead Structures
7. Screening Technologies for LeadDiscovery
8. Optimizationof Lead Structures
9. Designingprodrugs
10. Peptidomimetics
Part III Experimental and Theoretical Methods
11. Combinatorics: Chemistry With Big Numbers
12. Gene Technology in drug research
13. Experimental Methods of Structure Determination
14. The Spatial Structure of Biomolecules
15. Molecular Modelling
16. Conformational Analysis
Part IV Structure-Activity Relationships and Design Approaches
17.Pharmacophore Hypothesis and Molecular Comparisons
18. Quantitative Structure-ActivityRelationships
19. From in vitro to in vivo:Optimization of ADME-Tox Properties
20. ProteinModeling and Structure-BasedDrug Design
21. ACase Study: Structure-Based Inhibtor Design for tRNA-Guanine Transglycosylase
Part V. Drugs and drug action: Successes of stucture-based design
22. Howdrugs act: Concepts for therapy
23. Inhibitors of hydrolases With an acyl-enzymeintermediate
24. Asparticprotease inhibitors
25. Inhibitorsof hydrolysing metalloenzymes
26. Inhibitorsof transferases
27. Inhibitors ofoxidoreductases
28. Agonists and antagonistsof nuclear receptors
29. Agonists and antagonists of membrane-bound
30. Ligands forchannels, pores and transporters
31. Ligands for surfacereceptors
32. Biologicals: Peptides, proteins, nucleotidesand macrolides as drugs.