Dynamic contrast-enhanced MRI is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. The method assists clinical practitioners in the management of patients with solid tumors and is finding prominence in the assessment of tumor treatments, including anti-angiogenics, chemotherapy, and radiotherapy. Here, leading authorities discuss the principles of the methods, their practical implementation, and their application to specific tumor types. The text is an invaluable single-volume reference that covers all the latest developments in contrast-enhanced oncological MRI.

Alan Jackson, Professor of Neuroradiology at the University of Manchester, UK.

David Buckley, Lecturer in Magnetic Resonance Imaging at the University of Manchester, UK. Previous positions at the Universities of Florida, USA and Hull, UK.

Geoff Parker, Lecturer in Imaging Science at the University of Manchester, UK. Previous positions at the Institute of Neurology, London, UK and the Institute of Cancer Research, London, UK.

1;Foreword;6 2;Preface;7 3;Contents;9 4;Principles of Dynamic Contrast- Enhanced MRI;11 4.1;1 An Introduction to Dynamic Contrast-Enhanced MRI in Oncology;12 4.2;2 Contrast Agents for Magnetic Resonance Imaging;32 4.3;3 The Role of Blood Pool Contrast Media in the Study of Tumor Pathophysiology;47 4.4;4 Quantification of Dynamic Susceptibility Contrast T2* MRI in Oncology;61 4.5;5 Measuring Contrast Agent Concentration in T1- Weighted Dynamic Contrast- Enhanced MRI;76 4.6;6 Tracer Kinetic Modelling for T1- Weighted DCE- MRI;87 5;Imaging Techniques;99 5.1;7 Imaging Techniques for Dynamic Susceptibility Contrast- Enhanced MRI;100 5.2;8 Consensus Recommendations for Acquisition of Dynamic Contrasted- Enhanced MRI Data in Oncology;114 6;Clinical Applications;119 6.1;9 Dynamic Contrast-Enhanced MRI in Cerebral Tumours;120 6.2;10 Dynamic Magnetic Resonance Imaging in Breast Cancer;147 6.3;11 Dynamic Contrast-Enhanced MR Imaging for Predicting Tumor Control in Patients with Cervical Cancer;176 6.4;12 Dynamic Contrast-Enhanced MRI of Prostate Cancer;191 6.5;13 Dynamic Contrast-Enhanced MR Imaging in Musculoskeletal Tumors;214 6.6;14 Dynamic Contrast-Enhanced MRI in the Liver;237 7;Applications;260 7.1;15 Use of Dynamic Contrast-Enhanced MRI in Multi- Centre Trials with Particular Reference to Breast Cancer Screening in Women at Genetic Risk;261 7.2;16 Applications of Dynamic Contrast-Enhanced MRI in Oncology Drug Development;276 8;Subject Index;293 9;List of Contributors;302