This book equips dental care providers with a thorough understanding of the emerging therapies that promise to revolutionize the clinical management of periodontal diseases. Existing therapies targeted to the oral microbiome alone often fail to provide favorable clinical outcomes. Local inflammation and tissue destruction may persist and periodontal tissue regeneration is not predictably achieved. In recognition of these shortcomings, current research efforts are focused on understanding the biological interactions between the host and the resident microbiome and identifying key molecules and molecular pathways that can be used for more targeted, individualized therapies that will restrain oral inflammation and restore periodontal tissue homeostasis. This book introduces novel concepts and molecules that are currently being tested in preclinical and clinical models. Readers will find detailed information from leading experts on specific therapeutic strategies targeting the host immune and inflammatory system, the oral microbiome, and regeneration.  

PART I PERIODONTAL THERAPIES TARGETING HOST IMMUNE AND INFLAMMATORY SYSTEM Chapter 1 Evolving Paradigms in the Pathogenesis and Management of Periodontitis

Chapter 2 Complement C3 as a Target of Host Modulation in Periodontitis
Chapter 3 Resolvins in Periodontal Tissue Homeostasis (Emerging Therapies)
Chapter 4 Salicylic Acid Polymers in Periodontal Tissue Healing
Chapter 5 Targeting MAPK/MKP Signaling as a Therapeutic Axis in Periodontal Disease
Chapter 6 The IL17/Th17 Axis as a Therapeutic Target in Periodontitis
Chapter 7 Epigenetic and Gene Modification Precision Medicine Approaches for the 'Chronic Destructive Perio-Diseases': Periodontitis and Periimplantitis
Chapter 8 Cellular Senescence in Aging Mucosal Tissues is Accentuated by Periodontitis
Chapter 9 Peri-implant Disease.- PART II PERIODONTAL THERAPIES TARGETING ORAL MICROBIOME Chapter 10 The Function of the Oral Microbiome in Health and Disease
Chapter11 Bacterial Peptides Targeting Periodontal Pathogens in Communities
Chapter 12 Periodontal Pathogen Sialometabolic Activity in Periodontitis
Chapter 13 Ecological Approaches to Periodontal Therapy.- PART III TISSUE ENGINEERING FOR PERIODONTAL REGENERATION Chapter 14 Protein and Cell Based Therapies for Periodontal Regeneration
Chapter 15 Lasers in Periodontal and Peri-implant Therapy: Challenges and Opportunities
Chapter 16 Spatiotemporal Controls of Tooth-Supporting Structure Neogenesis by 3D Printing Technology