Approximately 10 years have elapsed since the first volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Endocrine System was completed. New information of interest to pathologists has developed at a rather remarkable pace during the intervening years. Exceptional progress has been made in the routine identification of cell products in endo crine cells. A better understanding has developed of the mechanisms involved in cell metabolism, particularly involving toxins and car cinogens. Clear concepts have developed concerning the significance of some pathologic lesions in the endocrine system and their relation to human health and risk assessment. Standardized nomenclature has developed significantly during the 1O-year period since the first volume and is being utilized on an international basis. This has resulted in significant improvement in communication of pathologic data to regulatory agencies and in scientific publications worldwide. This monograph series and others sponsored by ILSI have produced a significant effect on improved communications and the international acceptance of standardized nomenclature. In this second edition, new formats have been used where more appropriate for the subjects to be covered. In many cases, the format used in the first edition still is useful. It is still necessary to recognize the morphologic features of pathologic lesions in order to identify them precisely, an essential step toward development of new insights into pathogenetic mechanisms and their use in decisions eventually applicable to public health.

Pituitary

Functional and Pathologic Interrelationships of the Pituitary Gland and Hypothalamus in Animals
Histology, Ultrastructure, and Immunocytochemistry, Pituitary Gland, Rat
Function and Morphology of the Rat Pituitary Gland, Combined Investigations by Means of an In Vitro Model
Modern Approaches to Classification of Pituitary Tumors in Human Subjects and Animals
Histochemical Identification of Hormones in Pituitary Tumors, Rat
Adenoma and Carcinoma, Pars Distalis, Anterior Pituitary Gland, Rat
Adenoma, Pars Intermedia, Anterior Pituitary, Rat
Craniopharyngioma, Pituitary Gland, Rat
Pituitary Tumors Induced by Estrogen, Rat
Pituicytoma, Neurohypophysis, Rat
Gangliocytoma, Pituitary Gland, Rat
Pituitary Gland in the Human Growth-Releasing Factor Transgenic Mouse
Cysts, Pituitary, Rat, Mouse, and Hamster
Inflammation, Pituitary Gland: Rat, Mouse, and Hamster
Cystoid Degeneration Due to Diethylstilbestrol, Anterior Pituitary, Mouse
Craniopharyngeal Derivatives in the Neurohypophysis, Rat and Hamster
Hypothalamus
Stereotaxic Map, Cytoarchitectonic and Neurochemical Summary of the Hypothalamic Nuclei, Rat
Study of Pathologic Lesions in the Hypothalamic-Pituitary System, Rat
Hypothalamic-Pituitary Lesions Associated with Diabetes and Aging, Rat
Hypothalamic-Pituitary-Adrenal Axis of Genetically Obese fa/fa Rats
Pineal Gland
Functional Morphology of the Mammalian Pineal Gland
Tumors of the Pineal Gland, Rat
Thyroid
Hormonal Imbalances and Mechanisms of Chemical Injury of Thyroid Gland
Ectopic Thyroid, Mouse
Ectopic Thyroid, Rat
Ectopic Thymus, Thyroid, Rat
Follicular Cell Hyperplasia, Adenoma, and Carcinoma, Thyroid, Rat
Adenoma and Carcinoma, Thyroid Follicular Cell, Mouse
C-Cell Hyperplasia, C-Cell Adenoma,and C-Cell Carcinoma, Thyroid, Rat
Goiter, Nodular Hyperplasia, Adenoma, and Carcinoma of the Thyroid Induced by Amitrole and Ethylenethiourea, Rat
Ganglioneuroma, Thyroid Gland, Rat
Lymphocytic Thyroiditis, Rat
Parathyroids
Pathobiology of Parathyroid Gland Structure and Function in Animals
Anatomy, Histology, and Ultrastructure, Parathyroid, Syrian Hamster
Anatomy, Histology, and Ultrastructure, Parathyroid, Mouse
Anatomy, Histology, Ultra structure, Parathyroid, Rat
Ectopic Parathyroid, Mouse
Hyperplasia, Parathyroid, Syrian Hamster
Hyperplasia, Parathyroid, Rat
Adenoma, Parathyroid, Syrian Hamster
Adenoma, Carcinoma, Parathyroid, Rat
Pancreatic Islets
Hyperplasia, Adenoma, and Carcinoma of Pancreatic Islets, Mouse
Pancreatic Islet-Cell Hyperplasia, Golden Hamster
Adenoma and Carcinoma, Pancreatic Islets, Rat
Adrenals
Embryology, Adrenal Gland, Mouse
Histology, Adrenal Gland, Mouse
Accessory Adrenocortical Tissue, Mouse
Accessory Adrenocortical Tissue, Rat
Immunohistochemical and In Situ Hybridization Analysis of Steroidogenic Enzymes for Study of Steroid Metabolism in Endocrine Organs
Cell Proliferation in the Adult Adrenal Medulla: Chromaffin Cells as a Model for Indirect Carcinogenesis
Hyperplasia and Pheochromocytoma, Adrenal Medulla, Rat
Adrenal Medullary Tumors, Mouse
Ganglioneuroma, Adrenal, Rat
Neuroblastoma, Adrenal, Rat
Focal Hyperplasia, Adrenal Cortex; Rat
Adenoma, Adrenal Cortex, Rat
Adenocarcinoma, Adrenal Cortex, Rat
Adenoma and Carcinoma, Adrenal Cortex, Mouse
Amyloidosis, Adrenal, Mouse
Lipogenic Pigmentation, Adrenal Corex, Mouse
Lipogenic Pigmentation, Adrenal Cortex, Rat
Subcapsular-Cell Hyperplasia, Adrenal, Mouse
Chemically Induced Adrenocortical Degenerative Lesions
Nodular Cortical Hyperplasia, Adrenal, Thymectomized Mouse
Lipid Hyperplasia, Adrenal Cortex, Rat
Mouse Hepatitis Viral Infection, Adrenal, Mouse
Adrenovirus Infection, Adrenal, Mouse
Murine Cytomegalovirus Infection, Adrenal, Mouse
Polyoma Virus Infection, Adrenal, Mouse
Lymphocytic Choriomeningitis Virus Infection, Adrenal, Mouse
Adrenal Necrosis Due to Besnoitiosis, Golden Hamster.