Today, as the large international genome sequence projects are gaining a great amount of public attention and huge sequence data bases are created it be comes more and more obvious that we are very limited in our ability to access functional data for the gene products -the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often sub ject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible appli cations of that knowledge in the fields of medicine, agriculture, etc .. Recent pro gress on enzyme immobilization, enzyme production, enzyme inhibition, coen zyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. It is the functional profile of an enzyme that enables a biologist of physician to analyze a metabolic pathway and its disturbance; it is the substrate specificity of an enzyme which tells an analytical biochemist how to design an assay; it is the stability, specificity and efficiency of an enzyme which determines its usefulness in the biotechnical transformation of a molecule. And the sum of all these data will have to be considered when the designer of artificial biocatalysts has to choose the optimum prototype to start with.

6-Phosphofructo-2-kinase

Glucose-1,6-bisphosphate synthase
Diacylglycerol kinase
Dolichol kinase
[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
Dephospho-[reductase kinase] kinase
Protein-tyrosine kinase
Deoxyguanosine kinase
AMP-thymidine kinase
[3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase
[Isocitrate dehydrogenase (NADP+)] kinase
Myosin-light-chain kinase
ADP-thymidine kinase
Hygromycin-B kinase
Caldesmon kinase
Phosphoenolpyruvate-glycerone phosphotransferase
Xylitol kinase
Ca2+/calmodulin-dependent protein kinase
[Tyrosine 3-monooxygenase] kinase
Rhodopsin kinase
beta-Adrenergic-receptor kinase
1D-myo-Inositol-trisphosphate 3-kinase
[Acetyl-CoA carboxylase] kinase
Myosin-heavy-chain kinase
Tetraacyldisaccharide 4'-kinase
Low-density-lipoprotein kinase
Tropomyosin kinase
1D-myo-Inositol-trisphosphate 6-kinase
1D-myo-Inositol-tetrakisphosphate 1-kinase
Tau-protein kinase
Macrolide 2'-kinase
1-Phosphatidylinositol 3-kinase
Ceramide kinase
1D-myo-Inositol-trisphosphate 5-kinase
1D-myo-Inositol-tertrakisphosphate 5-kinase
[RNA-polymerase]-subunit kinase
Glycerol-3-phosphate-glucose phosphotransferase
Acetate kinase
Carbamate kinase
Phosphoglycerate kinase
Aspartate kinase
Formate kinase
Butyrate kinase
Acetylglutamate kinase
Phosphoglycerate kinase (GTP)
Glutamate 5-kinase
Acetate kinase (pyrophosphate)
Glutamate 1-kinase
Branched-chain-fatty-acid kinase
Guanidinoacetate kinase
Creatine kinase
Arginine kinase
Taurocyamine kinase
Lombricine kinase
Hypotaurocyamine kinase
Opheline kinase
Ammonia kinase
Phosphoenolpyruvate-protein phosphotransferase
Agmatine kinase
Protein-histidine pros-kinase
Protein-histidine tele-kinase.-Polyphosphate kinase
Phosphomevalonate kinase
Adenylate kinase
Nucleoside-phosphate kinase
Nucleoside-diphosphate kinase
Phosphomethylpyrimidine kinase
Guanylate kinase
dTMP kinase
Nucleoside-triphosphate-adenylate kinase
(Deoxy)adenylate kinase
T2-induced deoxynucleotide kinase
(Deoxy)nucleoside-phosphate kinase
Cytidylate kinase
Thiamine-diphosphate kinase
Thiamine-phosphate kinase
3-Phosphoglyceroyl-phosphate-polyphosphate phosphotransferase
Farnesyl-diphosphate kinase
5-Methyldeoxycytidine-5'-phosphate kinase
Dolichyl-diphosphate-polyphosphate phosphotransferase
Ribose-phosphate pyrophosphokinase
Thiamine pyrophosphokinase
2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Nucleotide pyrophosphokinase
GTP pyrophosphokinase
Nicotinamide-nucleotide adenylyltransferase
FMN adenylyltransferase
Pantetheine-phosphate adenylyltransferase
Sulfate adenylyltransferase
Sulfate adenylyltransferase (ADP)
DNA-directed RNA polymerase
DNA-directed DNA polymerase
Polyribonucleotide nucleotidyltransferase
UTP-glucose-1-phosphate uridylyltransferase
UTP-hexose-1-phosphate uridylyltransferase
UTP-xylose-1-phosphate uridylyltransferase
UDPglucose-hexose-1-phosphate uridylyltransferase
Mannose-1-phosphate guanylyltransferase
Ethanolamine-phosphate cytidylyltransferase
Choline-phosphate cytidylyltransferase
Nicotinate-nucleotide adenylyltransferase
Polynucleotide adenylyltransferase
tRNA cytidylyltransferase
Mannose-1-phosphate guanylyltransferase (GDP)
UDP-N-acetylglucosamine pyrophosphorylase
Glucose-1-phosphate thymidylyltransferase
tRNA adenylyltransferase
Glucose-1-phosphate adenylyltransferase
Nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase.-Hexose-1-phosphate guanylyltransferase
Fucose-1-phosphate guanylyltransferase
DNA nucleotidylexotransferase
Galactose-1-phosphate thymidylyltransferase
Glucose-1-phosphate cytidylyltransferase
Glucose-1-phosphate guanylyltransferase
Ribose-5-phosphate adenylyltransferase
Aldose-1-phosphate adenylyltransferase
Aldose-1-phosphate nucleotidyltransferase
3-Deoxy-manno-octulosonate cytidylyltransferase
Glycerol-3-phosphate cytidylyltransferase
D-Ribitol-5-phosphate cytidylyltransferase
Phosphatidate cytidylyltransferase
[Glutamate-ammonia-ligase] adenylyltransferase
N-Acylneuraminate cytidylyltransferase
Glucuronate-1-phosphate uridylyltransferase
Guanosine-triphosphate guanylyltransferase
Gentamicin 2"-nucleotidyltransferase
Streptomycin 3"-adenylyltransferase
RNA-directed RNA polymerase
RNA-directed DNA polymerase
mRNA guanylyltransferase
Adenylylsulfate-ammonia adenylyltransferase
RNA uridylyltransferase
ATP adenylyltransferase
Phenylalanine adenylyltransferase
Anthranilate adenylyltransferase
tRNA nucleotidyltransferase
N-Methylphosphoethanolamine cytidylyltransferase
(2,3-Dihydroxybenzoyl)adenylate synthase
Ethanolaminephosphotransferase
Diacylglycerol cholinephosphotransferase
Ceramide cholinephosphotransferase
Serine-phosphoethanolamine synthase
CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Undecaprenyl-phosphate galactosephosphotransferase
Holo-[acyl-carrier-protein] synthase
CDPdiacylglycerol-serine O-phosphatidyltransferase
Phosphomannan mannosephosphotransferase
Sphingosine cholinephosphotransferase
CDPdiacylglycerol-inositol 3-phosphatidyltransferase
CDPglycerol glycerophosphotransferase
Phospho-N-acetylmuramoyl-pentapeptide-transferase
CDPribitolribitolphosphotransferase
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase
UDPgalactose-UDP-N-acetylglucosamine galactosephosphotransferase
UDPglucose-glycoprotein glucosephosphotransferase
Phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase
Membrane-oligosaccharide glycerophosphotransferase
1-Alkenyl-2-acylglycerol cholinephosphotransferase
Pyruvate,orthophosphate dikinase
Pyruvate,water dikinase
Thiosulfate sulfurtransferase
3-Mercaptopyruvate sulfurtransferase
Thiosulfate-thiol sulfurtransferase
tRNA sulfurtransferase
Thiosulfate-dithiol sulfurtransferase
Aryl sulfotransferase
Alcohol sulfotransferase
Amine sulfotransferase
Estrone sulfotransferase
Chondroitin 4-sulfotransferase
Choline sulfotransferase
UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
Desulfoheparin sulfotransferase
Tyrosine-ester sulfotransferase
Renilla-luciferin sulfotransferase
Galactosylceramide sulfotransferase
Heparitin sulfotransferase
Psychosine sulfotransferase
Bile-salt sulfotransferase
Steroid sulfotransferase
Thiol sulfotransferase
Chondroitin 6-sulfotransferase
Cortisol sulfotransferase
Triglucosylalkylacylglycerol sulfotransferase
Protein-tyrosine sulfotransferase
Keratan sulfotransferase
Arylsulfate sulfotransferase
Heparin-glucosamine 3-O-sulfotransferase
Desulfoglucosinolate sulfotransferase
Flavonol 3-sulfotransferase
Quercetin-3-sulfate 3'-sulfotransferase
Quercetin-3-sulfate 4'-sulfotransferase
Quercetin-3,3'-bissulfate 7-sulfotransferase
Propionate CoA-transferase
Oxalate CoA-transferase
Malonate CoA-transferase
3-Oxoacid CoA-transferase.-3-Oxoadipate CoA-transferase
Succinate-citramalate CoA-transferase
Acetate CoA-transferase
Butyrate-acetoacetate CoA-transferase
Citrate-CoA transferase
Citramalate CoA-transferase
Glutaconate CoA-transferase
Succinate-hydroxymethylglutarate CoA-transferase
5-Hydroxypentanoate CoA-transferase.