This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy.

Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

Introduction

Epigenetics in Leukemia
Genetic and Epigenetic Alterations in Leukemia
Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment
Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation
DNA Methylation and Epigenetic Regulation
Chromatin Functional Regulation by Histone Modification
Approaches to Epigenetic Treatment of Leukemia
Proteomics in Leukemia
Proteome in Leukemic vs. Differentiated Leukemia Cells
Protein Phosphorylation in Leukemia
Computational Methods for Proteome Analysis
2DE Fractionation and Visualization
Proteomic Data Processing
Proteomic Data Analysis
Image Acquisition and Data Analysis
Image Acquisition and Data Analysis
Protein Localization in Leukemia
Protein Translocation into the Nucleus during Leukemia Cell Differentiation
Protein Visualization in Leukemic Cells
Computational Methods for Protein Localization Estimation
Fluorescent Image Processing
Fluorescent Image Acquisition and Analysis
Future Therapy in Leukemia
Index.