This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism's cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics.

This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person's biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis.

Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.

<p>Epitranscriptomic Modifications and How to Find them

Epitranscriptomic Signature in Neural Development and Disease
The Emerging Neuroepitranscriptome
Epitranscriptomics and Diseases
Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease
Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications
RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects
Computational Prediction and Experimental Validation of  Specific Modified RNA Sites
Regulation of RNA Stability Utilizing RNA Modification
Dynamic RNA Modification Upon Extracellular Stimulus
RNA Methylation in Cancer
Regulation of RNA Methylation yy TET Enzymes
RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria
RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target
Cap-Adjacent m⁶Am and its Effects On mRNA
N⁶-Methyladenosine in The Heart
The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis
Psivar: A Database of Functional Variants Involved in Pseudouridylation ( ) with Implications for Disease Pathogenesis
C-to-U RNA Editing by Mammalian APOBEC Enzymes
The Powerful Mechanism of RNA Editing and its Therapeutic Potentials
Noncanonical Caps in RNA
Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA
Dynamic mRNA Modifications in Plants
The Mammalian Mitochondrial Epitranscriptome
Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers
"Look Before You Leap" when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification
Functional Links Between the Internal <i>N6</i>-Methyl Adenosine Modifications in mRNAs and Human Diseases
RNA Modifications in Neurodevelopment and Neurodegenerations
Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts
Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation.-  Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases
RNA m6A and Adipogenesis.</p>