In the span of a few short years the therapeutic management of essential hypertension has been transformed from one of gross empiricism to that of a stable, rational approach based on established pharmacological principles. This success has required a close liaison among the disciplines of chemistry, of pharmacology, and of the clinic, for the niceties and fine nuances governing the relationship between chemical structure and type of biological activity of a compound are all too elusive for charting a reliable course through unfamiliar synthetic molecular configurations. Although autonomic nervous overactivity had never been demonstrably implicated as an etiological factor in essential hypertension, it had been realized earlier that suppression of this system by pharmacological means offered potential therapeutic benefit. Unfortunately, early investigative work had not yielded specific potent autonomic blocking agents with suf ficiently wide therapeutic indices to be suitable for human use. The initial successful surgical approach to the problem of sympathetic nervous dampen ing by means of a dorsal thoracolumbar sympathectomy established the validity of such a procedure and laid the groundwork for an ultimate pharmacological approach. Among the effective agents which have been discussed, an action either directly or indirectly upon the sympathetic nervous system or upon the neurohumors which it elaborates has been a common denominator. Such an occurrence inevitably poses the question as to whether such a common denominator has basic meaning or is merely coincidental with respect to the mode of action of the drug.

The mosaic theory of hypertension

Inheritance of high blood pressure
The nature of essential hypertension
Discussion
Possible role of salt intake in the development of essential hypertension
Renal hemodynamics, water and electrolyte excretion in essential hypertension
Discussion
Adrenocortical function and renal pressor mechanisms in experimental hypertension
Possible relationship between salt metabolism and the angiotensin system
Discussion
Adrenocortical function in essential hypertension
The significance of hyperaldosteronuria in hypertension
Discussion
Therapeutic aspects of salt restriction
Mechanism of hypotensive action of saluretics
Discussion
The natural history of benign hypertension
The natural course of malignant hypertension
Discussion
Pharmacology of new hypotensive drugs
Bretylium and guanethidine (clinical results)
Combined drug therapy of hypertension
Effects of the administration of saluretic drugs in the treatment of arterial hypertension
Discussion
Survival rates in severe hypertension intensively treated with hydralazine and ganglionic blockade
The late effects of hypotensive drug therapy on renal functions of patients with essential hypertension
Late results of surgical therapy (sympathectomy and adrenalectomy)
Discussion
Hypertension and its associated vascular diseases
Prevention and treatment of "atheromatous complications" of hypertension
Discussion
Closing remarks
List of authors.