For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.

5: Pharmacology of Estrogens and Antiestrogens

In Vitro and In Vivo Models to Characterise Estrogens and Antiestrogens
Estrogen Receptor ? in the Pharmacology of Estrogens and Antiestrogens
Interrelationship of Estrogens with other Hormones or Endocrine Systems
Mammary Gland
Cardiovascular System
Bone
Central Nervous System
Liver Inclusive Protein, Lipid and Carbohydrate Metabolism
Pharmacology of Antiestrogens
Oncology
Hormonal Resistance in Breast Cancer
Pharmacology of Inhibitors of Estrogen Biosynthesis
Pharmacology of Inhibition of Estrogen-Metabolizing Enzymes
Pharmacology of Different Administration Routes -Oral vs Transdermal
6: Kinetics and Toxicology of Estrogens and Antiestrogens
Pharmacokinetics of Exogenous Natural and Synthetic Estrogens and Antiestrogens
Toxicology of Estrogens and Antiestrogens
Estrogens and Sexually Transmitted Diseases
7: Clinical Application and Potential of Estrogens and Antiestrogens
Hormonal Contraception
Hormone Replacement Inclnding Osteoporosis
A. The Menopause
References
Gynaecological Disorders
A. Introduction
B. Primary Amenorrhoea
C. Secondary Amenorrhoea
D. Bleeding Problems
E. Anti-estrogens
References
Oncology
A. Breast Cance
B. Ovarian Cancer
C. Endometrial Cancer
References
Cardiology
A. Introduction
B. Epidemiological Association Between Oral ContraceptiveUse and Thrombosis
C. Oral Contraceptives and Hemostasis
D. Oral Contraceptives and Thrombophilia
E. Summary
References
Urogenital Ageing and Dermatology
A. Urogenital Aging
B. Dermatology
References
Geriatric Neurology and Psychiatry
A. Introduction
B. Estrogen and the Brain.
C. Estrogen, Mood, and Behavior
D. Estrogen and Cognition
E. Stroke
F. Dementia
G.Other Neuropsychiatric Disorders.
H. Conclusions
References
Estrogens and Antiestrogens in the Male
A. Introduction
B. Age-Related Changes of Estrogen Secretion
C. Metabolism and Pharmacokinetics of the Estrogens inthe Male
D. Genitourinary System
E. Mammary Gland
F. Liver
G. Bone
H. Cardiovascular System
I. Central Nervous System
J. The Influence of Environmental Estrogens (Xenoestrogens) on the Fertility of Men
K. Regimens for Estrogen and Antiestrogen Treatment in Men
L. The Therapeutic Value of Antiestrogens and Aromatase Inhibitors in Men
M. The Concept of Non-Feminizing Estrogens
References
8: Comparative Endocrinology
Comparative Aspects of Estrogen Biosynthesis and Metabolism and the Endocrinological Consequences in Different Animal Species
Therapeutic Use of Estrogens in Veterinary Medicine
9: Estrogens, Antiestrogens, and the Environment
Environmental Estrogens.