Covering all state-of-the-art experimental research methods in orthopedic surgery and trauma

From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this "roadmap" at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care.

Special Features:

- Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research- Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system- Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies spanning topics from fracture fixation to gait analysis to bone remodeling- Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function- Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering- Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study

With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians, Experimental Research Methods in Orthopedics and Trauma is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology

<p><strong>Part 1 Why Do We Need Experimental Research?</strong><br>1 Evidence-Based Research<br>2 Establishing a Basic Research Facility in Orthopedic Surgery<br>3 Good Laboratory Practice and Quality Control<br>4 How to Prepare for a Period in Research<br><strong>Part 2 Structural Biomechanics</strong><br>5 Physiological Boundary Conditions for Mechanical Testing<br>6 Static, Dynamic, and Fatigue Mechanical Testing<br>7 Use of Human and Animal Specimens in Biomechanical Testing<br>8 Whole Bone Biomechanics<br>9 Biomechanics of Trabecular and Cortical Bone<br>10 Biomechanics of Fracture Fixation<br>11 Biomechanical Assessment of Fracture Repair<br>12 Biomechanics of Cartilage<br>13 Biomechanics of Joints<br>14 Spine Biomechanics<br><strong>Part 3 Functional Biomechanics</strong><br>15 Musculokeletal Dynamics<br>16 Measurement Techniques<br>17 Clinical Assessment of Function<br>18 Functional Biomechanics with Cadaver Specimens<br><strong>Part 4 Numerical Biomechanics</strong><br>19 Inverse Dynamics<br>20 Principles of Finite Elements Analysis<br>21 Validation of Finite Element Models<br>22 Computational Biomechanics of Bone<br>23 Numerical Simulation of Implants and Prosthetic Devices<br>24 Numerical Simulation of Fracture Healing and Bone Remodelling<br><strong>Part 5 Imaging</strong><br>25 Micro-Computed Tomography Imaging of Bone Tissue<br>26 Imaging Bone<br>27 Ultrasound Techniques for Imaging Bone<br>28 In Vivo Scanning<br>29 Imaging of Cartilage Function<br>30 Histochemistry Bone and Cartilage<br>31 Immunohistochemistry<br>32 Molecular Imaging In Situ Hybridization<br>33 Laser Scanning Confocal Microscopy and Laser Microdissection<br>34 Image Analysis Histomorphometry Stereology<br><strong>Part 6 Cellular Studies</strong><br>35 Cell Culture Research<br>36 Cartilage Explants and Organ Culture Models<br>37 Fluid Flow and Strain in Bone<br>38 Biomechanics of Bone Cells<br><strong>Part 7 Molecular Techniques in Bone Repair</strong><br>39 Molecular Testing<br>40 Genetically Modified Models for Bone Repair<br><strong>Part 8 In Vivo Models</strong><br>41 General Considerations for an In Vivo Model<br>42 Animal Models for Bone Healing<br>43 Models for Impaired Healing<br>44 In Vivo Models for Bone and Joint Infections<br>45 In Vivo Models for Articular Cartilage Repair<br>46 In Vivo Soft Tissue Models<br><strong>Part 9 Tissue Engineering</strong><br>47 Scaffolds for Tissue Engineering and Materials for Repair<br>48 Use of Growth Factors in Musculoskeletal Research<br>49 Stem Cells for Musculoskeletal Repair<br>50 Biological Evaluation and Testing of Medical Devices<br><strong>Part 10 Statistics for Experimental Research</strong><br>51 Study Design<br>52 Power and Sample Size Calculation<br>53 Nonparametric versus Parametric Tests<br>54 How to Limit Bias in Experimental Research</p>