Today, as the large international genome sequence projects are gaining a great amount of public atte_ntion and huge sequence data bases are created it be comes more and more obvious that we are very limited in our ability to access functional data for the gene products - the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often sub ject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible appli cations of this knowledge in the fields of medicine, agriculture, etc .. Recent pro gress on enzyme immobilization, enzyme production, enzyme inhibition, coen zyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. It is the functional profile of an enzyme that enables a biologist or physician to analyse a metabolic pathway and its disturbance; it is the substrate specificity of an enzyme which tells an analytical biochemist how to design an assay; it is the stability, specificity and efficiency of an enzyme which determines its usefulness in the biotechnical transformation of a molecule. And the sum of all these data will have to be considered when the deSigner of artificial biocatalysts has to choose the optimum prototype to start with.

Acetoxybutynylbithiophene deacetylase

Acetylsalicylate deacetylase
Methylumbelliferyl-acetate deacetylase
2-Pyrone-4,6-dicarboxylate lactonase
N-Acetylgalactosaminoglycan deacetylase
Juvenile-hormone esterase
Bis(2-ethylhexyl)phthalate esterase
Protein-glutamate methylesterase
11-cis-Retinyl-palmitate hydrolase
all-trans-Retinyl-palmitate hydrolase
L-Rhamnono-1,4-lactonase
5-(3,4-Diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase
Fatty-acyl-ethyl-ester synthase
Xylono-1,4-lactonase
N-Acetylglucosaminylphosphatidylinositol deacetylase
Cetraxate benzylesterase
Ubiquitin thiolesterase
[Citrate-(pro-3S)-lyase] thiolesterase
(S)-Methylmalonyl-CoA hydrolase
ADP-dependent short-chain-acyl-CoA hydrolase
ADP-dependent medium-chain-acyl-CoA hydrolase
Acyl-CoA hydrolase
[3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase
Myosin-light-chain-phosphatase
Fructose-2,6-bisphosphate 6-phosphatase
Caldesmon-phosphatase
Inositol-1,4,5-trisphosphate 5-phosphatase
Inositol-1,4-bisphosphate 1-phosphatase
Sugar-terminal-phosphatase
Alkylacetylglycerophosphatase
Phosphoenolpyruvate phosphatase
Inositol-1,4,5-trisphosphate 1-phosphatase
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase
2-Carboxy-D-arabinitol-1-phosphatase
Phosphatidylinositol 3-phosphatase
Inositol-1,3-bisphosphate 3-phosphatase
Inositol-3,4-bisphosphate 4-phosphatase
Glycerophosphodiester phosphodiesterase
Variant-surface-glycoprotein phospholipase C
Dolichyl-phosphate-glucose phosphodiesterase
Dolichyl-phosphate-mannose phosphodiesterase
Glycoprotein phospholipase D
Glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase
Monomethyl-sulfatase
D-Lactate-2-sulfatase
Glucuronate-2-sulfatase
Aryldialkylphosphatase
Diisopropyl-fluorophosphatase
Deoxyribonuclease X
Ribonuclease IX
tRNA-intron endonuclease
rRNA endonuclease
1,3-alpha-L-Fucosidase
2-Deoxyglucosidase
Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Branched-dextran exo-1,2-alpha-glucosidase
Glucan 1,4-alpha-maltotriohydrolase
Amygdalin beta-glucosidase
Prunasin beta-glucosidase
Vicianin beta-glucosidase
Oligoxyloglucan beta-glycosidase
Polymannuronate hydrolase
Maltose-6'-phosphate glucosidase
Endoglycosylceramidase
3-Deoxy-2-octulosonidase
Raucaffricine beta-glucosidase
Coniferin beta-glucosidase
1,6-alpha-L-Fucosidase
Glycyrrhizinate beta-glucuronidase
Endo-alpha-sialidase
Glycoprotein endo-alpha-1,2-mannosidase
Xylan alpha-1,2-glucuronosidase
Chitosanase
Glucan 1,4-alpha-maltohydrolase
Difructose-anhydride synthase
Neopullulanase
Glucuronoarabinoxylan endo-1,4-beta-xylanase
Mannan exo-1,2-1,6-alpha-mannosidase
Anhydrosialidase
DNA-3-methyladenine glycosidase I
DNA-3-methyladenine glycosidase II
rRNA N-glycosidase
Formamidopyrimidine-DNA glycosidase
ADP-ribosyl-[dinitrogen reductase] hydrolase
Leukotriene-A4 hydrolase
Hepoxilin-epoxide hydrolase
Methionyl aminopeptidase
D-Stereospecific aminopeptidase
Aminopeptidase Ey
Non-stereospecific dipeptidase
Cytosol nonspecific dipeptidase
Membrane dipeptidase
beta-Ala-His dipeptidase
Tripeptidyl-peptidase l
Tripeptidyl-peptidase ll
X-Pro dipeptidyl-peptidase
Peptidyl-dipeptidase B
Peptidyl-dipeptidase Dcp
Carboxypeptidase C
Carboxypeptidase D
Glutamate carboxypeptidase
Carboxypeptidase M
Muramoyltetrapeptide carboxypeptidase
Zinc D-Ala-D-Ala carboxypeptidase
Carboxypeptidase A2
Membrane Pro-X carboxypeptidase
Tubulinyl-Tyr carboxypeptidase
Carboxypeptidase T
Carboxypeptidase Taq
beta-Aspartyl-peptidase
Pyroglutamyl-peptidase II
N-Formylmethionyl-peptidase
Pteroylpoly-gamma-glutamate carboxypeptidase
gamma-Glu-X carboxypeptidase
Acylmuramoyl-Ala peptidase
gamma-D-Glutamyl-meso-diaminopimelate peptidase I
Endopeptidase La
gamma-Renin
Venombin AB
Leucyl endopeptidase
Tryptase
Scutelarin
Kexin
Subtilisin
Oryzin
Endopeptidase K
Thermomycolin
Thermitase
Endopeptidase So
t-Plasminogen activator
Protein C (activated)
Pancreatic endopeptidase E
Pancreatic elastase II
IgA-specific serine endopeptidase
u-Plasminogen activator
Venombin A
Furin
Myeloblastin
Semenogelase
Granzyme A
Granzyme B
Streptogrisin A
Streptogrisin B
Glutamyl endopeptidase II
Oligopeptidase B
Limulus clotting factor C
Limulus clotting factor B
Limulus clotting enzyme
Omptin
Repressor LexA
Signal peptidase I
Togavirin
Flavivirin
Endopeptidase Clp
Proprotein convertase 1
Proprotein convertase 2.