Today, as the large international genome sequence projects are gaining a great amount of public attention and huge sequence data bases are created it be comes more and more obvious that we are very limited in our ability to access functional data for the gene products - the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from differentfields and are often sub ject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible appli cations of this knowledge in the fields of medicine, agriculture, etc.. Recent pro gress on enzyme immobilization, enzyme production, enzyme inhibition, coen zyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. It is the functional profile ofan enzyme that enables a biologist or physician to analyse a metabolicpathwayand its disturbance; it is the substrate specificityof an enzyme which tells an analytical biochemisthow to design an assay; it is the stability, specificityand efficiencyofan enzyme which determines its usefulness in the biotechnicaltransformation ofa molecule. Andthe sumofallthese data will have to be considered when the designerofartificial biocatalysts has to choose the optimum prototype to start with.

Cathepsin T

Glycyl endopeptidase
Cancer procoagulant
Cathepsin S
Picornain 3C
Picornain 2A
Caricain
Ananain
Stem bromelain
Fruit bromelain
Legumain
Histolysain
Interleukin 1beta converting enzyme
Gingipain R
Retropepsin
Pro-opiomelanocortin converting enzyme
Aspergillopepsin I
Aspergillopepsin II
Penicillopepsin
Rhizopuspepsin
Endothiapepsin
Mucorpepsin
Candidapepsin
Saccharopepsin
Rhodotorulapepsin
Physaropepsin
Acrocylindropepsin
Polyporopepsin
Pycnoporopepsin
Scytalidopepsin A
Scytalidopepsin B
Xanthomonapepsin
Cathepsin E
Barrierpepsin
Signal peptidase II
Pseudomonapepsin
Plasmepsin I
Plasmepsin II
Stromelysin 1
Meprin A
Procollagen C-endopeptidase
Peptidyl-Lys metalloendopeptidase
Astacin
Stromelysin 2
Matrilysin
Gelatinase A
Aeromonolysin
Pseudolysin
Thermolysin
Bacillolysin
Aureolysin
Coccolysin
Mycolysin
beta-Lytic metalloendopeptidase
Peptidyl-Asp metalloendopeptidase
Neutrophil collagenase
Gelatinase B
Leishmanolysin
Saccharolysin
Autolysin
Deuterolysin
Serralysin
Atrolysin B
Atrolysin C
Atroxase
Atrolysin E
Atrolysin F
Adamalysin
Horrilysin
Ruberlysin
Bothropasin
Bothrolysin
Ophiolysin
Trimerelysin I
Trimerelysin II
Mucrolysin
Pitrilysin
Insulysin
O-Sialoglycoprotein endopeptidase
Russellysin
Mitochondrial intermediate peptidase
Dactylysin
Nardilysin
Magnolysin
Meprin B
Mitochondrial processing peptidase
Macrophage elastase
Choriolysin L
Choriolysin H
Tentoxilysin
Bontoxilysin
Oligopeptidase A
Endothelin-converting enzyme 1
Fibrolase
Jararhagin
Thermopsin
Multicatalytic endopeptidase complex
N-Carbamoylputrescine amidase
Allophanate hydrolase
Long-chain-fatty-acyl-glutamate deacylase
N,N-Dimethylformamidase
Tryptophanamidase
N-Benzyloxycarbonylglycine hydrolase
N-Carbamoylsarcosine amidase
N-(Long-chain-acyl)ethanolamine deacylase
Mimosinase
Acetylputrescine deacetylase
4-Acetamidobutyrate deacetylase
Nalpha-Benzyloxycarbonylleucine hydrolase
Theanine hydrolase
2-(Hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
4-Methyleneglutaminase
N-Formylglutamate deformylase
Glycosphingolipid deacylase
Aculeacin-A deacylase
N-Feruloylglycine deacylase
D-Benzoylarginine-4-nitroanilide amidase
Carnitinamidase
Chenodeoxycholoyltaurine hydrolase
Urethanase
2,5-Dioxopiperazine hydrolase
N-Methylhydantoinase (ATP-hydrolysing)
Guanidinopropionase
Dimethylargininase
Ureidoglycolate hydrolase
Diguanidinobutanase
Methenyltetrahydromethanopterin cyclohydrolase
S-Adenosylhomocysteine deaminase
Cyanoalanine nitrilase
Arylacetonitrilase
Bromoxynil nitrilase
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
Guanosine-diphosphatase
Dolichyldiphosphatase
Oligosaccharide-diphosphodolichol pyrophosphatase
beta-Diketone hydrolase
2,6-Dioxo-6-phenylhexa-3-enoate hydrolase
2-Hydroxymuconate-semialdehyde hydrolase
Cyclohexane-1,3-dione hydrolase
Haloalkane dehalogenase
4-Chlorobenzoate dehalogenase
Trithionate hydrolase.