Today, as the large international genome sequence projects are gaining a great amount of public attention and huge sequence data bases are created it be comes more and more obvious that we are very limited in our ability to access functional data for the gene products - the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often sub ject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible appli cations of this knowledge in the fields of medicine, agriculture, etc .. Recent pro gress on enzyme immobilization, enzyme production, enzyme inhibition, coen zyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. It is the functional profile of an enzyme that enables a biologist or physician to analyse a metabolic pathway and its disturbance; it is the substrate specificity of an enzyme which tells an analytical biochemist how to design an assay; it is the stability, specificity and efficiency of an enzyme which determines its usefulness in the biotechnical transformation of a molecule. And the sum of all these data will have to be considered when the designer of artificial biocatalysts has to choose the optimum prototype to start with.

Pantothenoylcysteine decarboxylase

3,4-Dihydroxyphthalate decarboxylase
Glutaconyl-CoA decarboxylase
2-Oxoglutarate decarboxylase
Branched-chain-2-oxoacid decarboxylase
Tartrate decarboxylase
Fucosterol-epoxide lyase
4-(2-Carboxyphenyl)-2-oxobut-3-enoate aldolase
Propioin synthase
Lactate aldolase
Acetone-cyanhydrin lyase
Benzoin aldolase
(1-Hydroxycyclohexan-1-yl)acetyl-CoA lyase
Naphthoate synthase
Octadecanal decarbonylase
Trichodiene synthase
D(-)-Tartrate dehydratase
Xylonate dehydratase
4-Oxalmesaconate hydratase
Nitrile hydratase
Dimethylmaleate hydratase
16-Dehydroprogesterone hydratase
Octopamine dehydratase
Synephrine dehydratase
Carnitine dehydratase
L-Rhamnonate dehydratase
Carboxycyclohexadienyl dehydratase
Hydroperoxide dehydratase
ATP-dependent H4NAD(P)OH dehydratase
Scytalone dehydratase
Kievitone hydratase
Poly(alpha-L-guluronate) lyase
Xanthan lyase
beta-Pyrazolylalanine synthase (acetylserine)
L-Mimosine synthase
Uracilylalanine synthase
DNA-(apurinic or apyrimidinic site) lyase
Purine imidazole-ring cyclase
Peptidylamidoglycolate lyase
3-Ketovalidoxylamine C-N-lyase
Strictosidine synthase
Cyanate lyase
D-Cysteine desulfhydrase
Selenocysteine lyase
Holocytochrome-c synthase
Dichloromethane dehalogenase
L-2-Amino-4-chloropent-4-enoate dehydrochlorinase
S-Carboxymethylcysteine synthase
Pentalenene synthase
Cytidylate cyclase
Casbene synthase
(-)-endo-Fenchol synthase
Sabinene-hydrate synthase
Nocardicin-A epimerase
2-Chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
4-Hydroxyphenylacetaldehyde-oxime isomerase
Phosphoribosylanthranilate isomerase
Dopachrome DELTA-isomerase
Allene-oxide cyclase
Styrene-oxide isomerase
Phosphoenolpyruvate mutase
Isomaltulose synthase
tRNA-pseudouridine synthase I
Isobutyryl-CoA mutase
4-Carboxymethyl-4-methylbutenolide mutase
alpha-Pinene-oxide decyclase
Dichloromuconate cycloisomerase
O-Succinylbenzoate-CoA ligase
4-Hydroxybenzoate-CoA ligase
3alpha,7alpha-Dihydroxy-5beta-cholestanate-CoA ligase
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanate-CoA ligase
Phenylacetate-CoA ligase
2-Furoate-CoA ligase
Anthranilate-CoA ligase
Ubiquitin-calmodulin ligase
Diphthine-ammonia ligase
Homoglutathione synthase
Tyrosine-arginine ligase
Formate-dihydrofolate ligase.