Foot-and-Mouth Disease Virus
E-Book
Foot-and-Mouth Disease Virus
The chapters in this volume provide an account of the present knowledge and understanding of Foot and Mouth disease virus pathogenesis and global epidemiology, the detailed structure of the virus itself and the properties of its RNA genome. Also considered are the immune response of the host and the state of the art in vaccine production, and the nature of virus evolution. It is clear that in all these areas there is still much more to learn about this fascinating virus. Because of its highly contagious nature research work on FMDV is restricted to a small number of laboratories worldwide that have adequate containment facilities. Despite this restriction, the recent progress in research on FMDV which is described in this volume has provided a remarkable level of understanding of this unique virus.
1;Preface;5 2;List of Contents;7 3;List of Contributors;8 4;Introduction and History of Foot- and- Mouth Disease Virus;9 4.1;1 Introduction;10 4.2;2 The Virus;11 4.3;3 Serotypes;11 4.4;4 Genotypes;12 4.5;5 The World Reference Laboratory;12 4.6;6 Transmission and Spread of FMDV;13 4.7;7 Other Viruses Causing Vesicular Lesions;14 4.8;8 Vaccination;14 4.9;References;15 5;Foot-and-Mouth Disease: Host Range and Pathogenesis;17 5.1;1 Introduction;17 5.2;2 Host Range;18 5.3;3 Clinical Signs of the Disease and Pathogenesis;25 5.4;4 Conclusions;41 5.5;References;41 6;Translation and Replication of FMDV RNA;51 6.1;1 Introduction;52 6.2;2 Structure and Function of FMDV RNA;53 6.3;3 Features of the 50- UTR;53 6.4;4 Selection of Initiation Sites of Translation on FMDV RNA;59 6.5;5 Protein Interactions with the FMDV IRES;60 6.6;6 The Virus-Encoded Polyprotein;62 6.7;7 Structure and Function of the FMDV 30- UTR;69 6.8;8 Interaction Between Translation and Replication-Some Speculation;70 6.9;References;71 7;The Structure of Foot-and-Mouth Disease Virus;79 7.1;1 Introduction;80 7.2;2 Structural Overview;86 7.3;3 Capsid Stability and Permeability;87 7.4;4 Genome Penetration;89 7.5;5 Immunogenicity/Receptor Binding;89 7.6;6 Receptor Interactions;92 7.7;7 Heparan Sulphate Proteoglycan Receptors;93 7.8;8 The Structural Basis of Heparan Sulphate Recognition;94 7.9;9 Integrin Receptors;96 7.10;10 Virus-Integrin Complexes;97 7.11;11 Non-structural Proteins;97 7.12;12 Capsid Assembly;100 7.13;13 Concluding Remarks;101 7.14;References;102 8;Natural and Vaccine Induced Immunity to FMD;110 8.1;1 Natural Immunity;111 8.2;2 Vaccine-Induced Immunity;119 8.3;References;134 9;Global Epidemiology and Prospects for Control of Foot- and- Mouth Disease;139 9.1;1 Introduction;139 9.2;2 Epidemiology of Foot-and-Mouth Disease;140 9.3;3 Transmission of Foot-and-Mouth Disease Virus;141 9.4;4 Serotype O;144 9.5;5 Serotype A;146 9.6;6 Serotype C;147 9.7;7 Serotype ASIA 1;147 9.8;8 SAT Serotypes;148 9.9;9 Prospects for Control;149 9.10;10 Vaccination;149 9.11;11 Conclusion;152 9.12;References;152 10;Foot-and-Mouth Disease Virus Evolution: Exploring Pathways Towards Virus Extinction;155 10.1;1 Introduction: Concepts in RNA Virus Evolution;156 10.2;2 Accumulation of Deleterious Mutations: Rate, Mode, Mechanisms;160 10.3;3 Resistance to Extinction Despite Accumulation of Mutations: Observations and Modeling;164 10.4;4 Lethal Mutagenesis or the Transition into Error Catastrophe: A Pathway Towards Virus Extinction;168 10.5;5 Advantages and Limitations of Error Catastrophe as an Antiviral Strategy;172 10.6;6 Conclusions and Prospects;173 10.7;References;174 11;Subject Index;180
Mahy, Brian W. J.
| ISBN | 9783540271093 |
|---|---|
| Artikelnummer | 9783540271093 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2005 |
| Verlag | Springer-Verlag |
| Umfang | 178 Seiten |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
