Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.

<b><i>Part I Obesity. </i></b>Epidemiology of Obesity

The Circadian Clock and Obesity
Nutrition and Microbiome
From Obesity to Diabetes: The Role of the Adipose Organ
Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy
The Enteroendocrine System in Obesity
Insights from Studies of White Adipose Tissue Using Single-Cell Approaches.- Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction
Obesity, Senescence, and Senolytics.- Obesity and Obstructive Sleep Apnea.- <i>Part II Diabetes and Complications. </i>Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance
Islet Inflammation and beta Cell Dysfunction in Type 2 Diabetes
NAFLD and NASH: The Metabolically Diseased Liver
Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities
Diabetic Peripheral Neuropathy
<b><i>Part III Lifestyle Modifications and Future Treatments. </i></b>Weight Loss Strategies
PhysicalActivity, Obesity and Weight Loss Maintenance
Bariatric/Metabolic Surgery
Drugs for Treating Obesity
Novel Drugs for Diabetes Therapy.- Novel Approaches to Restore Pancreatic Beta-Cell Mass<br>and Function
Precision Medicine and Obesity
Targeting the Enteroendocrine System for Treatment of Obesity.