An authoritative work that provides a detailed review of the current status of cancer prevention and control practice and research. This volume is an essential reference guide and tool for primary care physicians, the research community and students.

Written as a collaborative work by the faculty of the nationally renowned Cancer Prevention and Control Program at the Arizona Cancer Center, this book brings together the expertise of specialists in the field of cancer prevention and control to provide the medical and research community that does not specialize in this field with insight to the disciplines of cancer prevention and control.

1;Contents;6 2;List of Contributors;16 3;Introduction to Cancer Prevention;20 3.1;1.1 Summary of Changes to Second Edition;22 3.2;1.2 Overview of Cancer Prevention;23 3.3;1.3 Multi- Step Carcinogenesis Pathway;26 3.4;1.4 Cancer Prevention Research;27 3.5;References;30 4;Assessing Human and Economic Benefits of Cancer Prevention;32 4.1;2.1 Outcomes Assessment;32 4.2;2.2 Humanistic Outcomes;33 4.3;2.3 Measuring Health- Related Quality of Life and Other Patient- Reported Outcomes;34 4.4;2.4 Economic Outcomes and Cancer;39 4.5;2.5 Defining and Measuring Economic Outcomes;40 4.6;2.6 Evaluative and Descriptive Analyses in Cancer Prevention;42 4.7;2.7 Conclusion;45 4.8;References;45 5;The Role of Diet, Physical Activity and Body Composition in Cancer Prevention;49 5.1;3.1 Introduction;49 5.2;3.2 Recommendations for Cancer Prevention: Body Weight, Diet, and Physical Activity;50 5.3;3.3 Diet and Cancer Prevention: Review of Evidence;51 5.4;3.4 Clearing the Muddied Waters: The Need for Improved Study Designs;54 5.5;3.5 Physical Activity and Cancer Prevention;56 5.6;3.6 Body Weight and Body Composition and Cancer Prevention;59 5.7;3.7 Lifestyle and Cancer Survivorship;61 5.8;3.8 Body Weight and Cancer Survival;62 5.9;3.9 Survivorship and Diet;63 5.10;3.10 Physical Activity and Cancer Survivorship;65 5.11;3.11 Optimizing Bone Health;67 5.12;3.12 Mechanisms of Carcinogenesis Modified by Lifestyle Factors;71 5.13;3.13 Biological Mechanisms by Which Physical Activity May Reduce Cancer Risk;76 5.14;3.14 Advancing the Guidelines for Cancer Preventive Lifestyle;78 5.15;3.15 Tools for Research and Clinical Practice;80 5.16;3.16 Measuring Diet;80 5.17;3.17 Assessment of Physical Activity and Energy Expenditure;82 5.18;3.18 Measurement of Body Composition;84 5.19;3.19 Measurement of Bone Health;86 5.20;3.20 Conclusion;87 5.21;References;89 6;Innate and Adaptive Immune Responses to Cancer;97 6.1;4.1 Importance of the Immune System in Cancer Prevention;97 6.2;4.2 Innate Immune Responses to Cancer;99 6.3;4.3 Adaptive Immune Response;107 6.4;4.4 Immunotherapy for Cancer Prevention;119 6.5;References;120 7;Hereditary Risk for Cancer;127 7.1;5.1 Cancer as a Genetic Disorder;127 7.2;5.2 Epigenetic Mechanisms;130 7.3;5.3 Cancer as a Hereditary Disease;130 7.4;5.4 Common Hereditary Cancer Syndromes;132 7.5;5.5 Genetic Counseling;139 7.6;5.6 Genetic Testing;143 7.7;5.7 Cancer Screening, Surveillance and Prophylactic Management for Hereditary Cancer Syndromes;146 7.8;5.8 Conclusion;149 7.9;References;149 8;Human Categories and Health: The Power of the Concept of Ethnicity;154 8.1;6.1 Introduction;154 8.2;6.2 Background;155 8.3;6.3 Race and the Failure of Attempts to Define Ethnicity;156 8.4;6.4 The Interactive View of Human Development;159 8.5;6.5 The Interactive View of Development and Health;162 8.6;6.6 Identifying Ethnicity Using Proxy Measures;166 8.7;6.7 Ethnicity and Health;167 8.8;6.8 Applications to Disparity Research;169 8.9;6.9 Conclusion;171 8.10;References;172 9;Complementary and Alternative Approaches to Cancer Prevention;175 9.1;7.1 CAM and Cancer Prevention Research;176 9.2;7.2 Botanical Agents: Foods, Spices, and Herbs;177 9.3;7.3 The Mind- Body Connection;181 9.4;7.4 Indigenous Cultural Systems of Healing;187 9.5;7.5 Conclusions;194 9.6;References;196 10;Telemedicine in Cancer Prevention;206 10.1;8.1 What is Telemedicine?;206 10.2;8.2 Telemedicine in Cancer Care;207 10.3;8.3 Primary Cancer Prevention;208 10.4;8.4 Secondary Prevention;211 10.5;8.5 Educating the Community Health Worker;216 10.6;8.6 Future Directions;217 10.7;References;217 11;The Drug Development Process;220 11.1;9.1 Selecting New Molecular Entities for Development as Chemopreventive Agents;221 11.2;9.2 Regulatory Requirements and the US Food and Drug Administration;222 11.3;9.3 The Investigational New Drug Application;223 11.4;9.4 Phases of Clinical Research;225 11.5;9.5 Good Clinical Practice;226 11.6;9.6 The New Drug Application;227 11.7;9.7 Conclusion;227 11.8;References;2